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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Systematic characterization of the immune response to gluten and casein in autism spectrum disorders

Principal Investigator

Principal Investigator

Alaedini, Armin

Description

Description

Wheat and milk proteins, including gluten and casein, have been suspected of having a role in autism spectrum disorders (ASD). However, while the rate of the use of gluten and/or casein exclusion diets in children with autism is increasing, the evidence for efficacy of these diets remains weak. At the same time, there is lack of consensus with regard to reports of elevated immune response to gluten and casein or increased concentrations of specific gluten and casein peptides in ASD. The aims of this project represent a systematic exploratory approach to examine the relevance of gluten and casein to ASD in a controlled study. ASD patients, celiac disease patients, and healthy individuals will be tested for levels of antibodies to gluten, casein, deamidated gluten, and the transglutaminase enzyme. The specificity of the immune response to the various gluten (gliadin and glutenin) and casein (alpha, beta, and kappa) molecules will be assessed by chromatography, mass spectrometry, and immunologic assays. Patient and control serum specimens will be assessed for the presence of specific gluten and casein peptides known to have opioid-like biological activity. The proposed experiments are expected to provide insight into the relevance of two commonly consumed groups of dietary proteins and the immune response against them in ASD. In addition, our proposed study to fully characterize the immune response to gluten and casein provides an opportunity to discover novel biomarkers that may become useful in identifying specific disease subtypes.

Funder

Funder

Department of Defense - Autism Research Program

Fiscal Year Funding

Fiscal Year Funding

0

Current Award Period

Current Award Period

2010-2012

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 2SA. Support at least four research projects to identify mechanisms of fever, metabolic and/or immune system interactions with the central nervous system that may influence ASD during prenatal-postnatal life by 2010. IACC Recommended Budget: $9,800,000 over 4 years. (Fever studies to be started by 2012.)

Project Link

Project Link

Systematic characterization of the immune response to gluten and casein in autism spectrum disorders (External web link)

Institution

Institution

Weill Cornell Medical College

State/Country

State/Country

New York

Project Number

Project Number

AR093487

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Systematic characterization of the immune response to gluten and casein in autism spectrum disorders | 126432 | 2009 | AR093487
Systematic characterization of the immune response to gluten and casein in autism spectrum disorders | 0 | 2010 | AR093487
Systematic characterization of the immune response to gluten and casein in autism spectrum disorders | 0 | 2011 | AR093487

 
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