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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Project 2: Immunological susceptibility of autism (supplement)

Principal Investigator

Principal Investigator

Van de Water, Judy

Description

Description

This is a supplement to a project funded in 2010 (5P01ES011269-10). Recent studies indicate that immune function in children with autism spectrum disorder (ASD) is profoundly altered compared to developmentally healthy controls. There is a strong interface between the immune system and the neurologic network, and successful neurodevelopment is contingent upon a successful interaction between these two systems. The study is one of three interrelated research projects at the University of California-Davis Center for Children's Environmental Health (CCEH) and will investigate both the serologic and cellular aspects of immune function in patients with autism to try to determine the underlying cellular mechanisms involved. From a cohort of children previously analyzed in the CHARGE study (Childhood Autism Risks from Genetics and Environment), children representing the entire ASD spectrum will be studied to evaluate the longitudinal serologic profile of children with ASD to determine which immune cell population(s) are crucial in the immune dysfunction seen in patients with autism and to fully characterize the autoantibody response in a subpopulation of children with ASD and some mothers of children with ASD.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

30784

Current Award Period

Current Award Period

2012-2013

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 2SA. Support at least four research projects to identify mechanisms of fever, metabolic and/or immune system interactions with the central nervous system that may influence ASD during prenatal-postnatal life by 2010. IACC Recommended Budget: $9,800,000 over 4 years. (Fever studies to be started by 2012.)

Project Link

Project Link

Project 2: Immunological susceptibility of autism (supplement) (External web link)

Institution

Institution

University of California, Davis

State/Country

State/Country

California

Project Number

Project Number

3P01ES011269-10S4

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

N/A

 
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