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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Tooth pulp as a source for neuronal precursor cells to study neurogenetic disorders

Principal Investigator

Principal Investigator

Reiter, Lawrence

Description

Description

The study of neurogenetic disorders via examination of gene/protein expression in post-mortem brain tissue or fibroblast (cell-type that synthesizes extracellular matrix and collagen) derived induced pluripotent stem cells (iPSCs) has several drawbacks. Current methods for fibroblast acquisition are highly invasive—fibroblast induction into stem cells may result in the loss of epigenetic integrity of the DNA, and iPSCs are limited in their future application for therapeutic transplantation due to the viral technologies employed to induce cell lines. In this project, investigators propose an alternative method employing dental pulp extracted from exfoliated primary teeth (EPT), as a source of stem cells for the study of a variety of neurogenetic syndromes such as autism spectrum disorder (ASD). Dental pulp stem cells differentiate into functional neurons in vitro and in vivo. Dental pulp from EPT are also an easily obtainable source of cranial neural crest (CNC) cells. The majority of the cells in the peripheral nervous system, including neurons, are derived from the neural crest. This novel approach will hopefully provide a fresh perspective to the way we study expression changes, epigenetics and neurophysiology in an ex-vivo model system for human neurogenetic disorders. Having these cultures could lead to new insights into the mechanisms of human neurogenetic disease as well as normal neuronal development and function.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

187344

Current Award Period

Current Award Period

2012-2014

Strategic Plan Question

Strategic Plan Question

Question 4: Which Treatments And Interventions Will Help?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.

Project Link

Project Link

Tooth pulp as a source for neuronal precursor cells to study neurogenetic disorders (External web link)

Institution

Institution

University of Tennessee Health Science Center

State/Country

State/Country

Tennessee

Project Number

Project Number

1R21NS075709-01A1

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

N/A

 
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