The study of neurogenetic disorders via examination of gene/protein expression in post-mortem brain tissue or fibroblast (cell-type that synthesizes extracellular matrix and collagen) derived induced pluripotent stem cells (iPSCs) has several drawbacks. Current methods for fibroblast acquisition are highly invasive—fibroblast induction into stem cells may result in the loss of epigenetic integrity of the DNA, and iPSCs are limited in their future application for therapeutic transplantation due to the viral technologies employed to induce cell lines. In this project, investigators propose an alternative method employing dental pulp extracted from exfoliated primary teeth (EPT), as a source of stem cells for the study of a variety of neurogenetic syndromes such as autism spectrum disorder (ASD). Dental pulp stem cells differentiate into functional neurons in vitro and in vivo. Dental pulp from EPT are also an easily obtainable source of cranial neural crest (CNC) cells. The majority of the cells in the peripheral nervous system, including neurons, are derived from the neural crest. This novel approach will hopefully provide a fresh perspective to the way we study expression changes, epigenetics and neurophysiology in an ex-vivo model system for human neurogenetic disorders. Having these cultures could lead to new insights into the mechanisms of human neurogenetic disease as well as normal neuronal development and function.