Recent genetic findings have identified mutations in synaptic cell adhesion genes and genes encoding their interacting protein partners at central synapses as genetic causes of autism spectrum disorders (ASDs). This research group has created several mutant mouse models of autism. In this project, these novel autism model mouse lines will be expanded and molecular, biochemical, electrophysiologic and behavioral characterization will be carried out. Behaviors corresponding to each of the three core symptom domains in autism spectrum disorder will be measured in these mouse lines. The marriage of understanding of brain pathology with behavioral abnormalities in these mice will lead to testable hypotheses regarding pharmacologic treatment of autism symptoms in the model and ultimately in autistic patients.