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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Novel genetic models of autism

Principal Investigator

Principal Investigator

Powell, Craig

Description

Description

Recent genetic findings have identified mutations in synaptic cell adhesion genes and genes encoding their interacting protein partners at central synapses as genetic causes of autism spectrum disorders (ASDs). This research group has created several mutant mouse models of autism. In this project, these novel autism model mouse lines will be expanded and molecular, biochemical, electrophysiologic and behavioral characterization will be carried out. Behaviors corresponding to each of the three core symptom domains in autism spectrum disorder will be measured in these mouse lines. The marriage of understanding of brain pathology with behavioral abnormalities in these mice will lead to testable hypotheses regarding pharmacologic treatment of autism symptoms in the model and ultimately in autistic patients.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

337875

Current Award Period

Current Award Period

2011-2016

Strategic Plan Question

Strategic Plan Question

Question 4: Which Treatments And Interventions Will Help?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.

Project Link

Project Link

Novel genetic models of autism (External web link)

Institution

Institution

University of Texas Southwestern Medical Center

State/Country

State/Country

Texas

Project Number

Project Number

5R01HD069560-02

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Novel genetic models of autism | 336813 | 2011 | 1R01HD069560-01
Novel genetic models of autism (supplement) | 99773 | 2012 | 3R01HD069560-02S1

 
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