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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Histone Methylation Mapping in Autism

Principal Investigator

Principal Investigator

Dincer, Aslihan

Description

Description

Epigenetics is the study of gene regulation and organization that occurs independent of changes in a gene’s “code,” or DNA sequence. Indeed, the vast majority of genes in a given cell remain off, or inactive, at a given time. As in other parts of the body, normal brain development and function depend on the right genetic “switches” being flipped on or off at the right time. Histone methylation is one such epigenetic switch. Autism scientists have speculated that increased risk of autism might result from problems in the control of gene expression in brain cells. Like DNA mutations, these epigenetic changes can be inherited and run in families. But they can also be caused by exposure to chemicals, lack of crucial nutrients and other many possible stresses This project will explore disease-associated roles of histone methylation. Because more than 98.5% of human genomic DNA does not encode protein sequence, the epigenetic fine mapping of brain cell genomes, including histone methylation, will be important in order to understand the potential role of the these vast portions of non-coding DNA for the neurobiology of autism.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

29500

Current Award Period

Current Award Period

2014-2016

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 3SJ. Support at least three studies that focus on the role of epigenetics in the etiology of ASD, including studies that include assays to measure DNA methylations and histone modifications and those exploring how exposures may act on maternal or paternal genomes via epigenetic mechanisms to alter gene expression, by 2012. IACC Recommended Budget: $20,000,000 over 5 years.

Project Link

Project Link

Histone Methylation Mapping in Autism (External web link)

Institution

Institution

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

State/Country

State/Country

New York

Project Number

Project Number

9099

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Histone Methylation Mapping in Autism | 29500 | 2014 | 9099

 
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