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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Development of a blood-based biomarker for autism

Principal Investigator

Principal Investigator

Sherr, Elliott

Description

Description

Autism is a complex disorder of many biological causes that results in characteristic behavioral symptoms. However, recent advances in the genetics of autism point to a constellation of genetic causes that converge on a subset of intracellular signaling pathways, including RAS-MAPK and PI3K/AKT, that may all contribute to autism, even if mutations in these pathways on their own may not be sufficient to cause the disorder. Elliott Sherr and his colleagues at the University of California, San Francisco are investigating the proteins in these and other signaling pathways to determine if the state of activation of these signaling proteins (often kinases and usually measured by the state of phosphorylation) are altered in a reproducible way in the white blood cells of individuals with autism. The group initially showed that the state of kinase activation was correlated with that measured in white blood cells and in the cerebral cortex. This observation suggests that it may be possible to develop a panel of markers in the blood of individuals with autism that would predict whether a child has autism prior to the onset of behavioral signs. Elliott Sherr and his team aim to test whether, in a replication cohort, the state of activation of these same proteins can reliably measure autism status in a group of children with autism and in matched controls. They also hope to investigate what other biological factors can influence this measurement.

Funder

Funder

Simons Foundation

Fiscal Year Funding

Fiscal Year Funding

124993

Current Award Period

Current Award Period

2014-2016

Strategic Plan Question

Strategic Plan Question

Question 1: When Should I Be Concerned?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 1LA. Identify behavioral and biological markers that separately, or in combination, accurately identify, before age 2, one or more subtypes of children at risk for developing ASD, and evaluate whether these risk markers or profiles can improve early identification through heightened developmental monitoring and screening by 2014. IACC Recommended Budget: $33,300,000 over 5 years.

Project Link

Project Link

Development of a blood-based biomarker for autism (External web link)

Institution

Institution

University of California, San Francisco

State/Country

State/Country

California

Project Number

Project Number

309212

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Development of a blood-based biomarker for autism | 62500 | 2014 | 309212

 
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