Skip to content
Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Characterization of synaptic and neural circuitry dysfunction underlying ASD-like behaviors using a novel genetic mouse model

Principal Investigator

Principal Investigator

Fu, Zhanyan

Description

Description

Shank3 mutant mice are mouse models of ASD. Dr. Fu will test the hypothesis that Shank3 disruption has differential effects on certain glutamatergic synapses*. The goal is to generate a novel mouse model of ASD harboring the deleterious Shank3 mutations from human patients with ASD, in order to yield clinically relevant insights into the underlying mechanism of human ASD and related disorders.

Funder

Funder

Brain & Behavior Research Foundation

Fiscal Year Funding

Fiscal Year Funding

0

Current Award Period

Current Award Period

2014-2016

Strategic Plan Question

Strategic Plan Question

Question 4: Which Treatments And Interventions Will Help?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.

Project Link

Project Link

No link available.

Institution

Institution

Duke University

State/Country

State/Country

North Carolina

Project Number

Project Number

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Characterization of synaptic and neural circuitry dysfunction underlying ASD-like behaviors using a novel genetic mouse model | 0 | 2012 | N/A
Characterization of synaptic and neural circuitry dysfunction underlying ASD-like behaviors using a novel genetic mouse model | 0 | 2013 |
Characterization of synaptic and neural circuitry dysfunction underlying ASD-like behaviors using a novel genetic mouse model | 15000 | 2014 |

 
Back to Top