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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Jones Lab Collaboration with the Autism Speaks (PACT)

Principal Investigator

Principal Investigator

Jones, Carrie

Description

Description

This project represents the addition of a new site to the Preclinical Autism Consortium for Therapeutics (PACT), a focused preclinical target selection and prosecution effort to de-risk the discovery and development of medicines aimed at treating the core diagnostic symptoms of autism. Studies at this site will evaluate different rat models with genetic mutations associated with autism to provide strong, replicable, corroborative behavioral and physiological phenotypes relevant to the symptoms of autism observed in patient populations. The project will identify robust phenotypes that may then be employed to evaluate selected compounds for symptom reversal. Demonstrating efficacy in multiple rodent models and standardized tests will increase confidence in specific pharmacological mechanisms of action for autism clinical trials.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

144372

Current Award Period

Current Award Period

2014-2016

Strategic Plan Question

Strategic Plan Question

Question 7: What Other Infrastructure and Surveillance Needs Must Be Met?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 7P. Provide resources to centers or facilities that develop promising vertebrate and invertebrate model systems, and make these models more easily available or expand the utility of current model systems, and support new approaches to develop high-throughput screening technologies to evaluate the validity of model systems by 2013. IACC Recommended Budget: $1,100,000 over 2 years.

Project Link

Project Link

Jones Lab Collaboration with the Autism Speaks (PACT) (External web link)

Institution

Institution

Vanderbilt University

State/Country

State/Country

Tennessee

Project Number

Project Number

9489

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Jones Lab Collaboration with the Autism Speaks (PACT) | 144372 | 2014 | 9489

 
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