Skip to content
Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Understanding the Genetic Architecture of Rett Syndrome - an Autism Spectrum Disorder

Principal Investigator

Principal Investigator

Krishnan, Keerthi

Description

Description

Keerthi Krishnan, Ph.D., Cold Spring Harbor Laboratory, will seek to unravel the pathogenesis of Rett syndrome, which falls on the spectrum of autism disorder. Rett syndrome is hypothesized to result from inappropriate neuronal maturation, function and plasticity. The study will advance methods of genomic analysis to characterize the altered gene expression of MeCP2 in relevant brain regions and examine the functionally relevant cells.

Funder

Funder

Brain & Behavior Research Foundation

Fiscal Year Funding

Fiscal Year Funding

30000

Current Award Period

Current Award Period

2014-2016

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.

Project Link

Project Link

No link available.

Institution

Institution

Cold Spring Harbor Laboratory

State/Country

State/Country

New York

Project Number

Project Number

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Understanding the Genetic Architecture of Rett Syndrome - an Autism Spectrum Disorder | 30000 | 2014 |
Understanding the Genetic Architecture of Rett Syndrome - an Autism Spectrum Disorder | 0 | 2013 |

 
Back to Top