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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

A Novel Glial Specific Isoform of Cdkl5: Implications for the Pathology of Autism in Rett Syndrome

Principal Investigator

Principal Investigator

Arikkath, Jyothi

Description

Description

Jyothi Arikkath, Ph.D., University of Nebraska Medical Center, will investigate how mutation in the gene CDKL5 leads to Rett syndrome, a neurodevelopmental disorder associated with ASD, epilepsy and intellectual disabilities. Alterations in synapses, the communication juncture between neurons, have been linked to the syndromes; the CDKL5 gene in cells called astrocytes is important for controlling the structure and function of synapses.

Funder

Funder

Brain & Behavior Research Foundation

Fiscal Year Funding

Fiscal Year Funding

60000

Current Award Period

Current Award Period

2014-2016

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.

Project Link

Project Link

No link available.

Institution

Institution

University of Nebraska

State/Country

State/Country

Nebraska

Project Number

Project Number

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

A Novel Glial Specific Isoform of Cdkl5: Implications for the Pathology of Autism in Rett Syndrome | 0 | 2014 |
A Novel Glial Specific Isoform of Cdkl5: Implications for the Pathology of Autism in Rett Syndrome | 0 | 2013 |

 
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