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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Statistical methodology and analysis of the Simons Simplex Collection and related data

Principal Investigator

Principal Investigator

Krieger, Abba

Description

Description

Since 2008, Abba Krieger, Andreas Buja and their colleagues in the statistics department at the Wharton School of the University of Pennsylvania have carried out various statistical analyses on genotype (genetically coded information) and phenotype (outward manifestation of that information) data from individuals with autism. Over this period they have collaborated with other SFARI autism researchers at the University of Michigan to analyze phenotype data. With collaborators at Cold Spring Harbor Laboratory, they have analyzed genotype data from the Simons Simplex Collection as well as behavioral, brain imaging, gene expression and genotype data from a genetic mouse model of autism. Krieger’s team has also developed data analysis and visualization software particularly suited for the rich data from these sources. Most recently they have collaborated on data related to maternal brain-specific antibodies, and on the selection and processing of essential phenotype variables for future phenotype-genotype association studies. Examples of such variables include measures of intelligence, daily living skills and social functioning. Future work may include analyzing data from the Simons Variation in Individuals Project, which recruits individuals on the basis of a common genetic abnormality, as opposed to an autism diagnosis.

Funder

Funder

Simons Foundation

Fiscal Year Funding

Fiscal Year Funding

197422

Current Award Period

Current Award Period

2013-2016

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 2SG. Support five studies that associate specific genotypes with functional or structural phenotypes, including behavioral and medical phenotypes (e.g., nonverbal individuals with ASD and those with cognitive impairments) by 2015. IACC Recommended Budget: $22,600,000 over 5 years.

Project Link

Project Link

Statistical methodology and analysis of the Simons Simplex Collection and related data (External web link)

Institution

Institution

University of Pennsylvania

State/Country

State/Country

Pennsylvania

Project Number

Project Number

296012

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Statistical methodology and analysis of the Simons Simplex Collection and related data | 142350 | 2014 | 296012
Statistical methodology and analysis of the Simons Simplex Collection and related data | 80389 | 2013 | 296012

 
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