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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Identification and Functional Analysis of Risk Genes for Autistic Macrocephaly

Principal Investigator

Principal Investigator

Sahara, Setsuko

Description

Description

Setsuko Sahara, Ph.D., Institute of Psychiatry, King’s College London, studies autistic macrocephaly, an enlargement of the brain seen in 20 percent of ASD patients. This project seeks to identify candidate genes and investigate their role in cortical development, in both mouse brains and induced-pluripotent stem cell-derived cortical progenitor cells gathered from patients with mutations of the candidate genes. The goal is to aid development of treatments tailored to specific subtypes of the disorder.

Funder

Funder

Brain & Behavior Research Foundation

Fiscal Year Funding

Fiscal Year Funding

30000

Current Award Period

Current Award Period

2014-2016

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 2SG. Support five studies that associate specific genotypes with functional or structural phenotypes, including behavioral and medical phenotypes (e.g., nonverbal individuals with ASD and those with cognitive impairments) by 2015. IACC Recommended Budget: $22,600,000 over 5 years.

Project Link

Project Link

No link available.

Institution

Institution

King's College London

State/Country

State/Country

United Kingdom

Project Number

Project Number

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Identification and Functional Analysis of Risk Genes for Autistic Macrocephaly | 30000 | 2014 |
Identification and Functional Analysis of Risk Genes for Autistic Macrocephaly | 0 | 2013 |

 
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