Skip to content
Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Serum antibody biomarkers for ASD

Principal Investigator

Principal Investigator

German, Dwight

Description

Description

Autism spectrum disorders (ASD) are neurodevelopmental disorders characterized by impairments in communication (verbal and nonverbal), social interactions, and stereotyped behaviors/interests. The etiology of ASD is not well understood, though it likely involves both genetic and environmental factors. Immune system dysfunction has been reported in ASD in many studies. Systemic immunologic alterations in autistic individuals often have been associated with autoimmunity; in particular, the generation of antibodies reactive against brain and central nervous system proteins. For example, both abnormalities in serum antibody concentrations and T cells have been reported for ASD compared to typically developing children. The goal of this grant proposal is to identify serum antibody biomarkers for ASD using a novel combinatorial peptoid library that has been successful for the identification of antibody biomarkers for Alzheimer's disease. An ASD blood biomarker would be very useful for early identification and targeted therapeutic intervention.

Funder

Funder

Department of Defense - Army

Fiscal Year Funding

Fiscal Year Funding

0

Current Award Period

Current Award Period

2012-2015

Strategic Plan Question

Strategic Plan Question

Question 1: When Should I Be Concerned?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 1LA. Identify behavioral and biological markers that separately, or in combination, accurately identify, before age 2, one or more subtypes of children at risk for developing ASD, and evaluate whether these risk markers or profiles can improve early identification through heightened developmental monitoring and screening by 2014. IACC Recommended Budget: $33,300,000 over 5 years.

Project Link

Project Link

Serum antibody biomarkers for ASD (External web link)

Institution

Institution

University of Texas Southwestern Medical Center

State/Country

State/Country

Texas

Project Number

Project Number

AR110172

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Identification of candidate serum antibody biomarkers for ASD | 118338 | 2012 | 202049
Identification of candidate serum antibody biomarkers for ASD | 112032 | 2013 | 202049
Identification of candidate serum antibody biomarkers for ASD | 0 | 2015 | 202049
Identification of candidate serum antibody biomarkers for ASD | 0 | 2014 | 202049
Serum antibody biomarkers for ASD | 570780 | 2011 | AR110172
Serum antibody biomarkers for ASD | 0 | 2012 | AR110172
Serum antibody biomarkers for ASD | 0 | 2013 | AR110172
Serum antibody biomarkers for ASD | 0 | 2014 | AR110172

 
Back to Top