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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Dysregulated Translation and Synaptic Dysfunction in Medium Spiny Neurons of Autism Model Mice

Principal Investigator

Principal Investigator

Klann, Eric

Description

Description

Eric Klann, Ph.D., Dr. Klann will test the hypothesis that exaggerated protein synthesis affecting a subpopulation of nerve cells called medium spiny neurons (MSNs) may lead to autism spectrum disorder (ASD) by causing synaptic dysfunction in the striatum region of the brain. Using mice models of ASD, the research will determine the subtype of MSNs that exhibit altered synaptic plasticity and identify their dysregulated proteins. The experiments should provide new insight into the molecular mechanisms whereby dysregulated protein synthesis in the striatum may result in the aberrant behavior of autism.

Funder

Funder

Brain & Behavior Research Foundation

Fiscal Year Funding

Fiscal Year Funding

33333

Current Award Period

Current Award Period

2014-2015

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

2O. Not specific to Question 2 objectives

Project Link

Project Link

No link available.

Institution

Institution

New York University

State/Country

State/Country

New York

Project Number

Project Number

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Dysregulated Translation and Synaptic Dysfunction in Medium Spiny Neurons of Autism Model Mice | 0 | 2013 |
Dysregulated Translation and Synaptic Dysfunction in Medium Spiny Neurons of Autism Model Mice | 66667 | 2014 |

 
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