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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Identifying a blood-based biomarker for Autism Spectrum Disorder-related inflammatory bowel disease

Principal Investigator

Principal Investigator

Walker, Stephen

Description

Description

Prospective studies have shown that the frequency of gastrointestinal symptoms may be as high as 70% in children with ASD; the majority showing inflammation of the ileum and/or colon. Gene expression profiling studies have suggested that the inflammation in the intestines of GI symptomatic ASD children may represent a unique type of bowel disease, one that is different from both Crohn’s disease and ulcerative colitis yet shares many of the molecular features of these conventional IBDs. Anecdotal reports suggest that treating underlying intestinal inflammation improves the quality of life of these children and their families and, in some cases, improves core autism features such as behavior and cognition. Gene expression profiling in bowel biopsy tissue is an important step in our understanding of autism as the data are derived from pathologically affected tissue. In our study, once the intestinal tissue gene expression profile is established we will seek to determine which of those same markers are present in peripheral blood as well. This will provide an objective and accurate blood test to aid in the diagnosis of ASD-associated inflammatory bowel disease (IBD) and may perhaps preclude the need to perform invasive and expensive ileocolonoscopies. Identification of such markers will also provide important information as to which genes are being “turned on” and “turned off” in patients with ASD-associated IBD thus providing potential targets for treatment of the bowel disease.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

60000

Current Award Period

Current Award Period

2014-2015

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 2SE. Launch three studies that target the underlying biological mechanisms of co-occurring conditions with autism, including seizures/epilepsy, sleep disorders, wandering/elopement behavior, and familial autoimmune disorders, by 2012. IACC Recommended Budget: $9,000,000 over 5 years.

Project Link

Project Link

Identifying a blood-based biomarker for Autism Spectrum Disorder-related inflammatory bowel disease (External web link)

Institution

Institution

Wake Forest University

State/Country

State/Country

North Carolina

Project Number

Project Number

9351

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Identifying a blood-based biomarker for Autism Spectrum Disorder-related inflammatory bowel disease | 60000 | 2014 | 9351

 
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