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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Endocannabanoid Enhancement of Sociability in Autism-related Mouse Models

Principal Investigator

Principal Investigator

Wei, Donghui

Description

Description

A growing number of parents of children with autism say they are considering treating their children with medical marijuana because of anecdotal reports of medical benefits of marijuana in subjects with autism. The first step in testing this theory is to examine the effects of the active principle in marijuana, ∆9-tetrahydrocannabinol, to see how it interacts with receptors in the brain that are thought to be involved in social interactions. Preliminary studies used a safe agent that enhances a marijuana-like chemical already produced in the brain, known as anandamide, that regulates mood and cognition. These studies found that enhancing anandamide completely corrects abnormal anandamide signaling and the social deficits observed in two well-established mouse models of autism. In this ASF-funded study, the researcher aims to test: (a) whether dysfunctional anandamide signaling contributes to asocial behavior; (b) how the biochemical signaling of anandamide causes its pro-social behavioral effects. This research will have important implications for both understanding the neurobiology of social deficits as well as the development of novel therapies for autism spectrum disorders.

Funder

Funder

Autism Science Foundation

Fiscal Year Funding

Fiscal Year Funding

0

Current Award Period

Current Award Period

2014-2015

Strategic Plan Question

Strategic Plan Question

Question 4: Which Treatments And Interventions Will Help?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.

Project Link

Project Link

Endocannabanoid Enhancement of Sociability in Autism-related Mouse Models (External web link)

Institution

Institution

University of California, Irvine

State/Country

State/Country

California

Project Number

Project Number

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Endocannabanoid Enhancement of Sociability in Autism-related Mouse Models | 25000 | 2014 |

 
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