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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Bioinformatics support for AGRE

Principal Investigator

Principal Investigator

No PI Listed

Description

Description

The Autism Genetic Resource Exchange (AGRE) is the first collaborative gene bank for the study of autism spectrum disorders. One of the world’s largest shared resources for the study of autism and related disorders, AGRE houses a collection of over 1300 well-characterized multiplex and simplex families made available to the greater scientific community. Founded by Cure Autism Now (CAN) in 1997, AGRE is currently funded by the National Institute of Mental Health (NIMH) and Autism Speaks (AS), which merged with CAN in 2006. Thanks to Autism Speaks and its thousands of supporters, AGRE will continue to serve as a moving force in the advancement of autism research. Complex neuropsychiatric disorders such as autism are best approached by collaborative research efforts that pool large samples to generate meaningful results. AGRE exists to serve researchers in the field of autism and, as such, is committed to meeting the needs of individual researchers, institutions, and collaborative research groups.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

59362

Current Award Period

Current Award Period

2006

Strategic Plan Question

Strategic Plan Question

Question 7: What Other Infrastructure and Surveillance Needs Must Be Met?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 7D. Establish and maintain an international network of biobanks for the collection of brain tissue, fibroblasts for pluripotent stem cells, and other tissue or biological material, by acquisition sites that use standardized protocols for phenotyping, collection, and regulated distribution of limited samples by 2011. o This includes support for post-processing of tissue, such as genotyping, RNA expression profiling, and MRI. o Protocols should be put into place to expand the capacities of ongoing large-scale children's studies to collect and store additional biomaterials, including newborn bloodspots, promoting detection of biological signatures. o Support should also be provided to develop an international web-based digital brain atlas that would provide high-resolution 3-D images and quantitative anatomical data from tissue of patients with ASD and disease controls across the lifespan, which could serve as an online resource for quantitative morphological studies, by 2014. IACC Recommended Budget: $82,700,000 over 5 years.

Project Link

Project Link

No link available.

Institution

Institution

Autism Speaks (AS)

State/Country

State/Country

New York

Project Number

Project Number

N/A

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Bioinformatics support for AGRE | 318287 | 2010 | n/a
Bioinformatics support for AGRE | 225936 | 2009 | Project number unavailable
Bioinformatics support for AGRE | 550514 | 2011 | N/A
Bioinformatics support for AGRE | 422519 | 2012 | N/A
Bioinformatics support for AGRE | 227208 | 2014 | N/A
Bioinformatics support for AGRE | 263552 | 2013 | N/A

 
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