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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Rhode Island population and genetics study of autism and intellectual disability

Principal Investigator

Principal Investigator

Morrow, Eric

Description

Description

Rhode Island is emerging as a national leader in innovative, integrated research and treatment for autism spectrum disorders. With regard to serving people with developmental disorders, the state has a deep tradition with strong relationships among academia, government, educators, service providers and families. Demographically, Rhode Island is a microcosm of the U.S.; it has a relatively stable population located within a small geographic region, which works well for longitudinal and population-based epidemiological studies. Eric Morrow is leading a new study involving a sizable proportion of the children and adults living in Rhode Island and surrounding communities who are affected by autism or related developmental disorders. The researchers aim to enroll participants who are representative of the Rhode Island population, after they are carefully assessed using the Autism Diagnostic Observation Schedule. The Rhode Island Consortium for Autism Research and Treatment (RI-CART), which represents the network of care and service providers participating in this study, includes clinicians from all major Rhode Island hospitals and behavioral health care centers, investigators from Brown University and its Alpert Medical School, educators from Rhode Island College, parents from a nationally recognized autism advocacy organization called The Autism Project, and representatives from the Rhode Island Department of Health and the Rhode Island Department of Education. Morrow’s team plans to enter their data, which will include biosamples such as DNA and cell samples, into the RI-CART de-identified research registry. The goals of the study are to develop a registry for future research involving genetic, population and treatment data. The researchers plan to share this resource with other qualified investigators. Plans to network RI-CART participants with other national efforts, including the Interactive Autism Network, are also in development.

Funder

Funder

Simons Foundation

Fiscal Year Funding

Fiscal Year Funding

608303

Current Award Period

Current Award Period

2013-2017

Strategic Plan Question

Strategic Plan Question

Question 7: What Other Infrastructure and Surveillance Needs Must Be Met?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 7D. Establish and maintain an international network of biobanks for the collection of brain tissue, fibroblasts for pluripotent stem cells, and other tissue or biological material, by acquisition sites that use standardized protocols for phenotyping, collection, and regulated distribution of limited samples by 2011. o This includes support for post-processing of tissue, such as genotyping, RNA expression profiling, and MRI. o Protocols should be put into place to expand the capacities of ongoing large-scale children's studies to collect and store additional biomaterials, including newborn bloodspots, promoting detection of biological signatures. o Support should also be provided to develop an international web-based digital brain atlas that would provide high-resolution 3-D images and quantitative anatomical data from tissue of patients with ASD and disease controls across the lifespan, which could serve as an online resource for quantitative morphological studies, by 2014. IACC Recommended Budget: $82,700,000 over 5 years.

Project Link

Project Link

Rhode Island population and genetics study of autism and intellectual disability (External web link)

Institution

Institution

Bradley Hospital

State/Country

State/Country

Rhode Island

Project Number

Project Number

286756

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Rhode Island population and genetics study of autism and intellectual disability | 308619 | 2014 | 286756
Rhode Island population and genetics study of autism and intellectual disability | 208799 | 2013 | 286756

 
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