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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Abnormal connectivity in autism

Principal Investigator

Principal Investigator

Clark, Kristi A.

Description

Description

Kristi A. Clark, Ph.D., University of California, Los Angeles, hopes to further understanding of the connectivity patterns in autism. One of the current dominant hypotheses is that autism can be characterized by an abnormal neuroanatomical connectivity pattern. Specifically, the hypothesis is one of local overconnectivity combined with long-distance underconnectivity. Graph theory methods, a form of mathematical modeling, have recently been applied to study of structural neuroanatomical connectivity using high angular resolution diffusion imaging (HARDI) data, which allows for the quantification of short-distance and long-distance connectivity. Dr. Clark and colleagues will test these methods in a pilot trial with autistic and nonautistic eight-year-old boys.

Funder

Funder

Brain & Behavior Research Foundation

Fiscal Year Funding

Fiscal Year Funding

0

Current Award Period

Current Award Period

2011-2017

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

2O. Not specific to Question 2 objectives

Project Link

Project Link

No link available.

Institution

Institution

University of California, Los Angeles

State/Country

State/Country

California

Project Number

Project Number

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Abnormal connectivity in autism | 15000 | 2011 | N/A
Abnormal connectivity in autism | 30000 | 2012 | N/A
Abnormal connectivity in autism | 15000 | 2013 |
Abnormal connectivity in autism | 0 | 2014 |
The microstructural basis of abnormal connectivity in autism | 348980 | 2009 | 1R01MH084795-01
The microstructural basis of abnormal connectivity in autism | 336355 | 2010 | 5R01MH084795-02
The microstructural basis of abnormal connectivity in autism | 332991 | 2011 | 5R01MH084795-03
The microstructural basis of abnormal connectivity in autism | 332991 | 2012 | 5R01MH084795-04
The microstructural basis of abnormal connectivity in autism | 276865 | 2013 | 7R01MH084795-05
The microstructural basis of abnormal connectivity in autism (supplement) | 226217 | 2012 | 3R01MH084795-04S1

 
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