|Project Title||Principal Investigator||Institution|
|Investigation of cortical folding complexity in children with autism, their autism-discordant siblings, and controls||Barnea-Goraly, Naama||Stanford University|
|Understanding perception and action in autism||Bastian, Amy||Kennedy Krieger Institute|
|Assessing information processing and capacity for understanding language in non-verbal children with autism||Benasich, April; Valerie Schafer||Rutgers University; City University of New York|
|Neural basis of audiovisual integration during language comprehension in autism||Bennetto, Loisa||University of Rochester|
|Past, present and future-oriented thinking about the self in children with ASD||Bowler, Dermot||City University, London|
|Development of brain connectivity in autism||Castellanos, F. Xavier; Lord, Catherine||New York University Medical College; University of Michigan|
|Oxidative stress and immune response in autism||Chauhan, Abha||New York State Institute for Basic Research in Developmental Disabilities|
|Cortical mechanisms underlying visual motion processing impairments in autism||Chen, Yue||Harvard Medical School|
|The neural correlates of transient and sustained executive control in children with autism spectrum disorder||Christ, Shawn||University of Missouri|
|Analysis of brain microstructure in autism using novel diffusion MRI approaches||Conturo, Thomas||Washington University School of Medicine|
|Stereological analyses of neuron numbers in frontal cortex from age 3 years to adulthood in autism||Courchesne, Eric||University of California, San Diego|
|Collaborative neuropathology workgroup: A comprehensive multilevel analysis of frontal lobe microstructure in autism||Courchesne, Eric||University of California, San Diego|
|Restricted and repetitive behaviors in young children with autism||Cuccaro, Michael||Duke University|
|Multisensory processing in autism||Essick, Gregory||University of North Carolina at Chapel Hill|
|Neural mechanisms of attentional networks in autism||Fan, Jin||Mount Sinai School of Medicine|
|Mimicry and imitation in ASDs||Fein, Deborah||University of Connecticut|
|Dendritic organization within the cerebral cortex in autism||Gabbott, Paul||The Open University|
|Neural basis of socially driven attention in children with autism||Greene, Deanna||University of California, Los Angeles|
|Communication and prosody in autism: A pilot fMRI study using a sib-pair design||Gusnard, Debra||Washington University in St. Louis|
|MRI study of brain development in school age children with autism||Hazlett, Heather Cody||University of North Carolina at Chapel Hill|
|Exploring functional brain connectivity for visual cognition in autism spectrum disorder||Joseph, Jane||University of Kentucky|
|Visuospatial processing in adults and children with autism||Just, Marcel||Carnegie Mellon University|
|Victimization, pragmatic language, and social and emotional competence in adolescents with ASD||Kelley, Elizabeth||Queen's University|
|Meg investigation of the neural substrates underlying visual perception in autism||Kenet, Tal||Massachussetts General Hospital|
|Investigation of the link between early brain enlargement and abnormal functional connectivity in autism spectrum disorders||Kleinhans, Natalia||University of Washington|
|IACC Strategic Plan Objectives||2008||2009||2010||2011||2012||Total|
|Complete a large-scale, multidisciplinary, collaborative project that longitudinally and comprehensively examines how the biological, clinical, and developmental profiles of individuals, with a special emphasis on females, youths, and adults with ASD, change over time as compared to typically developing people by 2020.
IACC Recommended Budget: $126,200,000 over 12 years
|2.L.A. Funding: The recommended budget was partially met.
Progress: Several projects have been funded in this area, and the ACE Network continues to collect data relevant to this objective.
Remaining Gaps, Needs and Opportunities: Though this research is underway, more clinical studies are needed over a longer trajectory to identify issues faced as people with ASD age, especially with regard to risk factors for other medical conditions. Another remaining need is that of standardization of data collection and analysis methods.