Strategic Plan Objective Detail
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Question 3: Objective 6  

$1,803,628.00
Fiscal Year: 2008

Yellow dot: Objective has some degree of funding, but less than the recommended amount.3.6 Determine the effect of at least five environmental factors on the risk for subtypes of ASD in the pre- and early postnatal period of development by 2015. IACC Recommended Budget: $25,100,000 over 7 years.

Download 2008 Question 3: Objective 6 projects (EXCEL)
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Project Title Principal Investigator Institution
Maternal risk factors for autism in the Nurses Health Study II – pilot study Ascherio, Alberto Harvard School of Public Health
Social determinants of the autism epidemic Bearman, Peter Columbia University
Project 1: Environmental epidemiology of autism Hertz-Picciotto, Irva University of California, Davis
Maternal supplementation of folic acid and function of autism gene synaptic protein Shank3 in animal model Jiang, Yong-Hui Baylor College of Medicine
Interactions of environment and molecular pathways on brain overgrowth in autism: Maternal inflammation and the PI3/AKT pathway Lebelle, Janel University of California, Los Angeles
Immune biomarkers in serum and newborn dried blood spots No PI listed Centers for Disease Control and Prevention
Influence of the maternal immune response on the development of autism Ponzio, Nicholas University of Medicine & Dentistry of New Jersey
Influence of maternal cytokines on activation of the innate immune system as a factor in the development of autism Ponzio, Nicholas University of Medicine & Dentistry of New Jersey
Influence of maternal cytokines during pregnancy on effector and regulatory T helper cells as etiological factors in autism Ponzio, Nicholas University of Medicine & Dentistry of New Jersey
Assisted reproductive treatments and risk of autism Reichenberg, Avi Institute of Psychiatry, King's College London
Maternal dietary factors and risk of ASDs Santangelo, Susan Harvard Medical School
Early developmental risk factors for autism in a national birth cohort Sourander, Andre Turku University
Immunobiology in autism Van de Water, Judy University of California, Davis

Objective Cumulative Funding Table

IACC Strategic Plan Objectives 2008 2009 2010 2011 2012 Total
Determine the effect of at least five environmental factors on the risk for subtypes of ASD in the prenatal and early postnatal period of development by 2015.

IACC Recommended Budget: $25,100,000 over 7 years
3.6
$1,803,628
13 projects

3.L.C
$1,992,228
10 projects

3.L.C
$820,320
10 projects

3.L.C
$379,913
5 projects

3.L.C
$353,000
5 projects

$5,349,089
3.L.C. Funding: The recommended budget was partially met, and several projects were funded, but it appears there is a downward trend in funding for these projects over time. This objective partially overlaps with 3.L.A.

Progress: Epidemiological studies coded to other objectives (e.g., EARLI) may also represent progress in this area.

Remaining Gaps, Needs, and Opportunities:  A barrier to the completion of this objective is the undefined nature of ASD subtypes, both phenotypically and etiologically, lack of prenatal samples, and the lack of longitudinal follow-up of at-risk subgroups. This field is still developing and needs support.