Interagency Autism Coordinating Committee (IACC)
Autism Research Database (AFD)
| Project Element | Element Description |
|---|---|
Project TitleProject Title |
The role of the new mTOR complex, mTORC2, in autism spectrum disorders |
Principal InvestigatorPrincipal Investigator |
Costa-Mattioli, Mauro |
DescriptionDescription |
Mutations in TSC and PTEN, two negative regulators of mTORC1 are associated with ASD. The hypothesis is that cognitive and social in several ASD mouse models is caused by dysregulation of mTORC2 rather than mTORC1 activity. This proposal combines biochemical, transgenic, pharmacological, electrophysiological, imaging, and behavioral approaches to explore several crucial aspects of mTORC2 function in ASD pathology, including its role in synaptic plasticity, memory social behavior, and the downstream molecular mechanisms by which mTORC2 regulates ASD-related behaviors. |
FunderFunder |
Department of Defense - Army |
Funding CountryFunding Country |
United States |
Fiscal Year FundingFiscal Year Funding |
0 |
Current Award PeriodCurrent Award Period |
2013-2016 |
Strategic Plan QuestionStrategic Plan Question |
Question 2: What is the Biology Underlying ASD? |
Funder’s Project LinkFunder’s Project Link |
External Project Page
|
InstitutionInstitution |
Baylor College of Medicine |
Institute LocationInstitute Location |
United States |
Project NumberProject Number |
AR120254 |
Government or PrivateGovernment or Private |
Government |
History/Related ProjectsHistory/Related Projects |
The role of the new mTOR complex, mTORC2, in autism spectrum disorders |
625998
| 2012 |
AR120254
|
