Daniel H Ebert, M.D., Ph.D., at Johns Hopkins University School of Medicine will investigate a genetic mutation that causes Rett syndrome, a disorder with features of autism. Major gaps in knowledge remain in understanding how this mutation regulates gene expression in the brain and how dysfunction of this gene leads to neuropsychiatric disorders. Dr. Ebert will explore a hypothesized interaction between this gene and a molecular system in the brain called the NCoR co-repressor complex. He hopes findings from this study will advance understanding of molecular mechanisms that contribute to the development of a range of neuropsychiatric disorders including autism.
Interagency Autism Coordinating Committee (IACC)
Autism Research Database (AFD)
