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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Project Element Element Description

Project Title

Project Title

Abnormal connectivity in autism

Principal Investigator

Principal Investigator

Clark, Kristi

Description

Description

Kristi A. Clark, Ph.D., University of California, Los Angeles, hopes to further understanding of the connectivity patterns in autism. One of the current dominant hypotheses is that autism can be characterized by an abnormal neuroanatomical connectivity pattern. Specifically, the hypothesis is one of local overconnectivity combined with long-distance underconnectivity. Graph theory methods, a form of mathematical modeling, have recently been applied to study of structural neuroanatomical connectivity using high angular resolution diffusion imaging (HARDI) data, which allows for the quantification of short-distance and long-distance connectivity. Dr. Clark and colleagues will test these methods in a pilot trial with autistic and nonautistic eight-year-old boys.

Funder

Funder

Brain & Behavior Research Foundation

Funding Country

Funding Country

United States

Fiscal Year Funding

Fiscal Year Funding

14881

Current Award Period

Current Award Period

2011-2017

Strategic Plan Question

Strategic Plan Question

Question 2: What is the Biology Underlying ASD?

Funder’s Project Link

Funder’s Project Link

No URL available.

Institution

Institution

University of Southern California

Institute Location

Institute Location

United States

Project Number

Project Number

Government or Private

Government or Private

Private

History/Related Projects

History/Related Projects

Abnormal connectivity in autism | 15000 | 2011 | N/A
Abnormal connectivity in autism | 30000 | 2012 | N/A
Abnormal connectivity in autism | 15000 | 2013 |
Abnormal connectivity in autism | 0 | 2014 |
Abnormal connectivity in autism | 0 | 2015 |
Abnormal connectivity in autism | 0 | 2017 |
The microstructural basis of abnormal connectivity in autism | 348980 | 2009 | 1R01MH084795-01
The microstructural basis of abnormal connectivity in autism | 336355 | 2010 | 5R01MH084795-02
The microstructural basis of abnormal connectivity in autism | 332991 | 2011 | 5R01MH084795-03
The microstructural basis of abnormal connectivity in autism | 332991 | 2012 | 5R01MH084795-04
The microstructural basis of abnormal connectivity in autism | 276865 | 2013 | 7R01MH084795-05
The microstructural basis of abnormal connectivity in autism (supplement) | 226217 | 2012 | 3R01MH084795-04S1

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