Autism Research Database - Location Project Details | IACC

Project Element	Element Description
Project Title Project Title	Developmental Role of Prefrontal Cortex-raphe Circuits in Stress and Mood Disorders
Principal Investigator Principal Investigator	Soiza-Reilly, Mariano
Description Description	Mariano Soiza-Reilly, Ph.D., of INSERM, France, will study the development and maturation of neural pathways connecting the medial prefrontal cortex (mPFC and the dorsal raphe nucleus, which are involved in stress and emotional responses and are impaired in mood disorders. Does dysregulation of this process contribute to vulnerability to stress and mood disorders? The team will use a new technique called array tomography along with in utero electroporation to selectively visualize and manipulate the activity of neural circuits. This may provide new insights into the possible role of mPFC neurons in the developmental origins of stress-related and mood disorders and will provide a plausible neural substrate for developing preventive tools and therapeutics.
Funder Funder	Brain & Behavior Research Foundation
Funding Country Funding Country	United States
Fiscal Year Funding Fiscal Year Funding	17500
Current Award Period Current Award Period	2016-2018
Strategic Plan Question Strategic Plan Question	Question 2: What is the Biology Underlying ASD?
Funder’s Project Link Funder’s Project Link	No URL available.
Institution Institution	INSERM
Institute Location Institute Location	France
Project Number Project Number
Government or Private Government or Private	Private
History/Related Projects History/Related Projects	Developmental Role of Prefrontal Cortex-raphe Circuits in Stress and Mood Disorders \| 35000 \| 2017 \| Developmental Role of Prefrontal Cortex-raphe Circuits in Stress and Mood Disorders \| 0 \| 2018 \|

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