Autism Research Database - Principal Investigator Project Details | IACC

Project Element	Element Description
Project Title Project Title	The role of the new mTOR complex, mTORC2, in autism spectrum disorders
Principal Investigator Principal Investigator	Costa-Mattioli, Mauro
Description Description	Mutations in TSC and PTEN, two negative regulators of mTORC1 are associated with ASD. The hypothesis is that cognitive and social in several ASD mouse models is caused by dysregulation of mTORC2 rather than mTORC1 activity. This proposal combines biochemical, transgenic, pharmacological, electrophysiological, imaging, and behavioral approaches to explore several crucial aspects of mTORC2 function in ASD pathology, including its role in synaptic plasticity, memory social behavior, and the downstream molecular mechanisms by which mTORC2 regulates ASD-related behaviors.
Funder Funder	Department of Defense - Army
Funding Country Funding Country	United States
Fiscal Year Funding Fiscal Year Funding	0
Current Award Period Current Award Period	2013-2016
Strategic Plan Question Strategic Plan Question	Question 2: What is the Biology Underlying ASD?
Funder’s Project Link Funder’s Project Link	External Project Page
Institution Institution	Baylor College of Medicine
Institute Location Institute Location	United States
Project Number Project Number	AR120254
Government or Private Government or Private	Government
History/Related Projects History/Related Projects	The role of the new mTOR complex, mTORC2, in autism spectrum disorders \| 625998 \| 2012 \| AR120254 The role of the new mTOR complex, mTORC2, in autism spectrum disorders \| 0 \| 2013 \| AR120254 The role of the new mTOR complex, mTORC2, in autism spectrum disorders \| 0 \| 2014 \| AR120254 The role of the new mTOR complex, mTORC2, in autism spectrum disorders \| 0 \| 2015 \| AR120254

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