Autism Research Database - Principal Investigator Project Details | IACC

Project Element	Element Description
Project Title Project Title	Autism Linked LRRTM4-Heparan Sulphate Proteoglycan Complex Functions in Synapse Development
Principal Investigator Principal Investigator	Siddiqui, Tabrez
Description Description	Tabrez J. Siddiqui, Ph.D., University of British Columbia, Canada, studies synapses, and specifically, alterations in proteins that organize and maintain them, which have been implicated in ASD, schizophrenia, ADHD and intellectual disability. This project, using mice, will test the theory that disruption of a protein complex called LRRTM4-HSPG impairs cognitive function and underlies certain forms of ASD by altering brain connections.
Funder Funder	Brain & Behavior Research Foundation
Funding Country Funding Country	United States
Fiscal Year Funding Fiscal Year Funding	0
Current Award Period Current Award Period	2014-2016
Strategic Plan Question Strategic Plan Question	Question 2: What is the Biology Underlying ASD?
Funder’s Project Link Funder’s Project Link	No URL available.
Institution Institution	University of Manitoba
Institute Location Institute Location	Canada
Project Number Project Number
Government or Private Government or Private	Private
History/Related Projects History/Related Projects	Autism Linked LRRTM4-Heparan Sulphate Proteoglycan Complex Functions in Synapse Development \| 0 \| 2013 \| Autism Linked LRRTM4-Heparan Sulphate Proteoglycan Complex Functions in Synapse Development \| 29479 \| 2015 \| Autism Linked LRRTM4-Heparan Sulphate Proteoglycan Complex Functions in Synapse Development \| 30000 \| 2014 \| Autism Linked LRRTM4-Heparan Sulphate Proteoglycan Complex Functions in Synapse Development \| 15000 \| 2017 \|

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