Autism Research Database - Principal Investigator Project Details | IACC

Project Element	Element Description
Project Title Project Title	Modeling Pitt-Hopkins Syndrome, an Autism Spectrum Disorder, in Transgenic Mice Harboring a Pathogenic Dominant Negative Mutation in TCF4
Principal Investigator Principal Investigator	Thaxton, Courtney
Description Description	Courtney L. Thaxton, Ph.D., University of North Carolina, Chapel Hill, studies Pitt-Hopkins Syndrome (PTHS), on the spectrum of autism disorder, that is caused by de novo mutation(s) or partial deletion(s) in a single copy of a gene called TCF4. She seeks to develop a new mouse model of TCF4 that better mimics human PTHS so she can study symptom onset function of TCF4 in the nervous system.
Funder Funder	Brain & Behavior Research Foundation
Funding Country Funding Country	United States
Fiscal Year Funding Fiscal Year Funding	0
Current Award Period Current Award Period	2014-2016
Strategic Plan Question Strategic Plan Question	Question 2: What is the Biology Underlying ASD?
Funder’s Project Link Funder’s Project Link	No URL available.
Institution Institution	University of North Carolina at Chapel Hill
Institute Location Institute Location	United States
Project Number Project Number
Government or Private Government or Private	Private
History/Related Projects History/Related Projects	Modeling Pitt-Hopkins Syndrome, an Autism Spectrum Disorder, in Transgenic Mice Harboring a Pathogenic Dominant Negative Mutation in TCF4 \| 0 \| 2013 \| Modeling Pitt-Hopkins Syndrome, an Autism Spectrum Disorder, in Transgenic Mice Harboring a Pathogenic Dominant Negative Mutation in TCF4 \| 30000 \| 2014 \| Modeling Pitt-Hopkins Syndrome, an Autism Spectrum Disorder, in Transgenic Mice Harboring a Pathogenic Dominant Negative Mutation in TCF4 \| 0 \| 2015 \|

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