Autism Research Database - Principal Investigator Project Details

Project Element	Element Description
Project Title Project Title	Brain Somatic Mosaicism at ASD-Associated Loci
Principal Investigator Principal Investigator	Keil, Jason
Description Description	Many studies have investigated genetic mutations that arise from sperm and egg, called germline mutations. However, some recent research has also investigated mutations that occur in tissue that is generated after the embryo has formed. These types of mutations, called somatic mutations, are found in some cells but not others, resulting in mosaicism. Somatic mutations have been well studied in cancer and other brain disorders but, until now, not autism. The findings of this project will better illustrate whether neural somatic mosaicism may contribute to cortical development and neural circuitry.
Funder Funder	Autism Science Foundation
Funding Country Funding Country	United States
Fiscal Year Funding Fiscal Year Funding	0
Current Award Period Current Award Period	2015-2016
Strategic Plan Question Strategic Plan Question	Question 2: What is the Biology Underlying ASD?
Funder’s Project Link Funder’s Project Link	External Project Page
Institution Institution	University of Michigan
Institute Location Institute Location	United States
Project Number Project Number
Government or Private Government or Private	Private
History/Related Projects History/Related Projects	Brain Somatic Mosaicism at ASD-Associated Loci \| 25000 \| 2015 \| Brain Somatic Mosaicism at ASD-Associated Loci \| 0 \| 2017 \|