Interagency Autism Coordinating Committee (IACC)
Autism Research Database (AFD)
Project Element | Element Description |
---|---|
Project TitleProject Title> |
Anti-Neuronal Autoantibodies against Bacterial Polysaccharides in Autism Spectrum Disorders |
Principal InvestigatorPrincipal Investigator |
Cunningham, Madeleine |
DescriptionDescription |
Autoantibodies against brain and bacterial polysaccharides are not well characterized in Autism Spectrum Disorders (ASD). Anti-streptococcal autoantibodies are well characterized in Rheumatic Fever and Sydenham chorea (SC) by human monoclonal antibodies (mAbs) and Immunoglobulin G (IgG) derived from SC. SC is a prototype movement and neuropsychiatric disorder recognized for autoimmunity developing from a bacterial infection. Other bacterial polysaccharides may play an important role in crossreactivity with brain such as in Streptococcus pneumoniae and Haemophilus influenzae type b. These studies are expected to determine potential antibody risk factors and potentially diagnostic tools to subset Autistic children for better diagnosis scales and more effective treatment if immune dysregulation is the underlying cause of some of their symptoms. |
FunderFunder |
Autism Speaks |
Funding CountryFunding Country |
United States |
Fiscal Year FundingFiscal Year Funding |
0 |
Current Award PeriodCurrent Award Period |
2014-2016 |
Strategic Plan QuestionStrategic Plan Question |
Question 2: What is the Biology Underlying ASD? |
Funder’s Project LinkFunder’s Project Link |
External Project Page
|
InstitutionInstitution |
University of Oklahoma Health Sciences Center |
Institute LocationInstitute Location |
United States |
Project NumberProject Number |
9535 |
Government or PrivateGovernment or Private |
Private |
History/Related ProjectsHistory/Related Projects |
Anti-Neuronal Autoantibodies against Bacterial Polysaccharides in Autism Spectrum Disorders |
0
| 2015 |
9535
|