Autism Research Database - Principal Investigator Project Details | IACC

Project Element	Element Description
Project Title Project Title	Rebuilding Inhibition in the Autistic Brain
Principal Investigator Principal Investigator	Paradis, Suzanne
Description Description	Suzanne Paradis, Ph.D., Brandeis University, will investigate the potential of a protein her lab discovered, Sem4D, to restore the balance of excitation and inhibition in the brain. Neurons in the brain connect with one anvia two kinds of synapses - excitatory synapses, which promote information propagation, and inhibitory synapses, which prevent it. The balance between excitatory and inhibitory synapses is thought to be disrupted in the brains of people with autism. Sema4D causes new inhibitory synapses to form very rapidly, suggesting it may be a useful therapeutic.
Funder Funder	Brain & Behavior Research Foundation
Funding Country Funding Country	United States
Fiscal Year Funding Fiscal Year Funding	49680
Current Award Period Current Award Period	2015-2017
Strategic Plan Question Strategic Plan Question	Question 2: What is the Biology Underlying ASD?
Funder’s Project Link Funder’s Project Link	No URL available.
Institution Institution	Brandeis University
Institute Location Institute Location	United States
Project Number Project Number
Government or Private Government or Private	Private
History/Related Projects History/Related Projects	Rebuilding Inhibition in the Autistic Brain \| 24840 \| 2015 \| Rebuilding Inhibition in the Autistic Brain \| 0 \| 2014 \| Rebuilding Inhibition in the Autistic Brain \| 24840 \| 2017 \|

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