Autism Research Database - Principal Investigator Project Details | IACC

Project Element	Element Description
Project Title Project Title	Regulation of an Activity-dependent Transcription Factor by MeCP2
Principal Investigator Principal Investigator	Ebert, Daniel
Description Description	Daniel H Ebert, M.D., Ph.D., at Johns Hopkins University School of Medicine will investigate a genetic mutation that causes Rett syndrome, a disorder with features of autism. Major gaps in knowledge remain in understanding how this mutation regulates gene expression in the brain and how dysfunction of this gene leads to neuropsychiatric disorders. Dr. Ebert will explore a hypothesized interaction between this gene and a molecular system in the brain called the NCoR co-repressor complex. He hopes findings from this study will advance understanding of molecular mechanisms that contribute to the development of a range of neuropsychiatric disorders including autism.
Funder Funder	Brain & Behavior Research Foundation
Funding Country Funding Country	United States
Fiscal Year Funding Fiscal Year Funding	35000
Current Award Period Current Award Period	2016-2018
Strategic Plan Question Strategic Plan Question	Question 3: What Causes ASD, and Can Disabling Aspects of ASD be Prevented or Preempted?
Funder’s Project Link Funder’s Project Link	No URL available.
Institution Institution	Johns Hopkins University School of Medicine
Institute Location Institute Location	United States
Project Number Project Number
Government or Private Government or Private	Private
History/Related Projects History/Related Projects	Regulation of an Activity-dependent Transcription Factor by MeCP2 \| 17500 \| 2017 \| Regulation of an Activity-dependent Transcription Factor by MeCP2 \| 0 \| 2018 \|

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