Autism Research Database - Principal Investigator Project Details | IACC

Project Element	Element Description
Project Title Project Title	Study of a potentially novel biomarker for features of ASD
Principal Investigator Principal Investigator	Subramanian, Megha
Description Description	Many individual genetic variants contribute to ASD, but newer evidence emphasizes how these genes converge on a common set of pathways controlling the growth, development, shape and function of brain cells. In some people with autism, head size is enlarged starting very young, suggesting a type of autism that has specific genetic features. A biomarker that reflects fundamental differences in brain growth might be useful for early detection of ASD. This study will focus on small fragments of RNA called microRNA (miRNA) that control protein synthesis. Specifically, dysregulation of some miRNAs may lead to too much or too little protein in certain cells. The levels of these miRNAs can be measured in blood, which makes it a potential biomarker, and this project will reveal how specific miRNA pathways contribute to head growth in ASD.
Funder Funder	Autism Science Foundation
Funding Country Funding Country	United States
Fiscal Year Funding Fiscal Year Funding	25000
Current Award Period Current Award Period	2016-2017
Strategic Plan Question Strategic Plan Question	Question 2: What is the Biology Underlying ASD?
Funder’s Project Link Funder’s Project Link	External Project Page
Institution Institution	Johns Hopkins University
Institute Location Institute Location	United States
Project Number Project Number
Government or Private Government or Private	Private
History/Related Projects History/Related Projects	Study of a potentially novel biomarker for features of ASD \| 0 \| 2017 \|

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