Interagency Autism Coordinating Committee (IACC)
Autism Research Database (AFD)
| Project Element | Element Description |
|---|---|
Project TitleProject Title |
Altered placental tryptophan metabolism: A crucial molecular pathway for the fetal programming of neurodevelopmental disorders |
Principal InvestigatorPrincipal Investigator |
Bonnin, Alexandre |
DescriptionDescription |
The PI hypothesizes that maternal inflammation alters TRP metabolism in the placenta by perturbing the 5-hydroxytryptophan (5- HT) and kynurenine pathways, which has significant consequences for neurodevelopment. The PI's specific aims are: 1) To determine whether maternal inflammation alters placental synthesis and fetal exposure of 5-HT and kynurenine-pathway compounds; 2) To characterize the inflammation-mediated alternations of TRP metabolism effects on fetal brain neurochemistry and postnatal brain structure; 3) To determine if genetic or pharmacological manipulations of placental TRP metabolic pathways in vivo can reduce inflammation effect on offspring brain development. |
FunderFunder |
Department of Defense - Army |
Funding CountryFunding Country |
United States |
Fiscal Year FundingFiscal Year Funding |
0 |
Current Award PeriodCurrent Award Period |
2013-2016 |
Strategic Plan QuestionStrategic Plan Question |
Question 2: What is the Biology Underlying ASD? |
Funder’s Project LinkFunder’s Project Link |
External Project Page
|
InstitutionInstitution |
University of Southern California |
Institute LocationInstitute Location |
United States |
Project NumberProject Number |
AR120066 |
Government or PrivateGovernment or Private |
Government |
History/Related ProjectsHistory/Related Projects |
Altered placental tryptophan metabolism: A crucial molecular pathway for the fetal programming of neurodevelopmental disorders |
535699
| 2012 |
AR120066
|
