Autism Research Database - Strategic Plan Question Project Details | IACC

Project Element	Element Description
Project Title Project Title	Mechanisms of synaptic alterations in a neuroinflammation model of autism
Principal Investigator Principal Investigator	Dunaevsky, Anna
Description Description	The hypothesis is that altered expression of cytokines and chemokines in the brains of offspings exposed to maternal immune activation (MIA) results in impaired synaptic development and altered behavior. Specific aims are: 1) Study how synapses are altered in offspring challenged with MIA; 2) Study the synapses development in the presence of chemokines and cytokines; 3) Determine if alteration in synapse and social behavior can be altered by anti-neuroinflammatory drug.
Funder Funder	Department of Defense - Army
Funding Country Funding Country	United States
Fiscal Year Funding Fiscal Year Funding	0
Current Award Period Current Award Period	2013-2016
Strategic Plan Question Strategic Plan Question	Question 2: What is the Biology Underlying ASD?
Funder’s Project Link Funder’s Project Link	External Project Page
Institution Institution	University of Nebraska Medical Center
Institute Location Institute Location	United States
Project Number Project Number	AR120096
Government or Private Government or Private	Government
History/Related Projects History/Related Projects	Mechanisms of synaptic alterations in a neuroinflammation model of autism \| 579882 \| 2012 \| AR120096 Mechanisms of synaptic alterations in a neuroinflammation model of autism \| 0 \| 2013 \| AR120096 Mechanisms of synaptic alterations in a neuroinflammation model of autism \| 0 \| 2015 \| AR120096 Mechanisms of synaptic alterations in a neuroinflammation model of autism \| 0 \| 2014 \| AR120096

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