Autism Research Database - Strategic Plan Question Project Details | IACC

Project Element	Element Description
Project Title Project Title	Anti-Neuronal Autoantibodies against Bacterial Polysaccharides in Autism Spectrum Disorders
Principal Investigator Principal Investigator	Cunningham, Madeleine
Description Description	Autoantibodies against brain and bacterial polysaccharides are not well characterized in Autism Spectrum Disorders (ASD). Anti-streptococcal autoantibodies are well characterized in Rheumatic Fever and Sydenham chorea (SC) by human monoclonal antibodies (mAbs) and Immunoglobulin G (IgG) derived from SC. SC is a prototype movement and neuropsychiatric disorder recognized for autoimmunity developing from a bacterial infection. Other bacterial polysaccharides may play an important role in crossreactivity with brain such as in Streptococcus pneumoniae and Haemophilus influenzae type b. These studies are expected to determine potential antibody risk factors and potentially diagnostic tools to subset Autistic children for better diagnosis scales and more effective treatment if immune dysregulation is the underlying cause of some of their symptoms.
Funder Funder	Autism Speaks
Funding Country Funding Country	United States
Fiscal Year Funding Fiscal Year Funding	0
Current Award Period Current Award Period	2014-2016
Strategic Plan Question Strategic Plan Question	Question 2: What is the Biology Underlying ASD?
Funder’s Project Link Funder’s Project Link	External Project Page
Institution Institution	University of Oklahoma Health Sciences Center
Institute Location Institute Location	United States
Project Number Project Number	9535
Government or Private Government or Private	Private
History/Related Projects History/Related Projects	Anti-Neuronal Autoantibodies against Bacterial Polysaccharides in Autism Spectrum Disorders \| 0 \| 2015 \| 9535 Anti-Neuronal Autoantibodies against Bacterial Polysaccharides in Autism Spectrum Disorders \| 100000 \| 2014 \| 9535

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