Autism Research Database - Strategic Plan Question Project Details | IACC

Project Element	Element Description
Project Title Project Title	Identification of Genetic Mutations in Consanguineous Families with Autism Spectrum Disorders using Whole Exome Sequencing
Principal Investigator Principal Investigator	Vasli, Nasim
Description Description	Nasim Vasli, Ph.D., Centre for Addiction and Mental Health, University of Toronto, Canada, will assess 100 Iranian patients with autism spectrum disorder (ASD and their parents, all from related-by-blood (consanguineous marriages, in order to probe genetic causes of their disorder and to detect new autosomal recessive (AR genes via whole-genome sequencing. In autosomal recessive diseases, two copies of an abnormal gene must be present for a disease or trait to develop. The team will attempt to further validate any AR genes in a cohort of 200 ASD cases and their parents, to assess which of the genes are most frequently disrupted.
Funder Funder	Brain & Behavior Research Foundation
Funding Country Funding Country	United States
Fiscal Year Funding Fiscal Year Funding	0
Current Award Period Current Award Period	2016-2019
Strategic Plan Question Strategic Plan Question	Question 3: What Causes ASD, and Can Disabling Aspects of ASD be Prevented or Preempted?
Funder’s Project Link Funder’s Project Link	No URL available.
Institution Institution	The Hospital for Sick Children
Institute Location Institute Location	Canada
Project Number Project Number
Government or Private Government or Private	Private
History/Related Projects History/Related Projects	Identification of Genetic Mutations in Consanguineous Families with Autism Spectrum Disorders using Whole Exome Sequencing \| 52500 \| 2017 \| Identification of Genetic Mutations in Consanguineous Families with Autism Spectrum Disorders using Whole Exome Sequencing \| 0 \| 2018 \| Identification of Genetic Mutations in Consanguineous Families with Autism Spectrum Disorders using Whole Exome Sequencing \| 0 \| 2019 \|

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