The Autism Genetic Resource Exchange (AGRE) is the first collaborative gene bank for the study of autism spectrum disorders. One of the world’s largest shared resources for the study of autism and related disorders, AGRE houses a collection of over 1300 well-characterized multiplex and simplex families made available to the greater scientific community. Founded by Cure Autism Now (CAN) in 1997, AGRE is currently funded by the National Institute of Mental Health (NIMH) and Autism Speaks (AS), which merged with CAN in 2006. Thanks to Autism Speaks and its thousands of supporters, AGRE will continue to serve as a moving force in the advancement of autism research.Complex neuropsychiatric disorders such as autism are best approached by collaborative research efforts that pool large samples to generate meaningful results. AGRE exists to serve researchers in the field of autism and, as such, is committed to meeting the needs of individual researchers, institutions, and collaborative research groups.