Strategic Plan Objective Detail
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Question 1: Objective 3  

Fiscal Year: 2008

Yellow dot: Objective has some degree of funding, but less than the recommended amount.1.3 Identify a panel of biomarkers that separately, or in combination with behavioral measures, accurately identify, before age 2, one or more subtypes of children at risk for developing ASD by 2014. IACC Recommended Budget: $33,300,000 over 5 years.

Download 2008 Question 1: Objective 3 projects (EXCEL)
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Project Title Principal Investigator Institution
Clinical and gene signatures of ASDs Lewis, Suzanne University of British Columbia
Family study of autism: Genomic and proteomic markers Smith, Christopher Southwest Autism Research & Resource Center
Identifying gastrointestinal (GI) conditions in children with autism spectrum disorders (ASD) Winter, Harland Harvard Medical School
Integrated Biostatistical and Bioinformatic Analysis Core (IBBAC) Schork, Nicholas University of California, San Diego
Linguistic and social responses to speech in infants at risk for autism Kuhl, Patricia University of Washington
Metabolic biomarkers of autism: Predictive potential and genetic susceptibility James, Sandra Arkansas Children's Hospital Research Institute
Mis-regulation of BDNF in autism spectrum disorders Hempstead, Barbara Weill Cornell Medical College
Mitochondria and autism Wallace, Douglas; Gargus, Jay; Golomb, Beatrice; Haas, Richard; Naviaux, Robert; Barshop, Bruce University of California, Irvine; University of California, San Diego
Mitochondrial defects in autism Shoffner, John Georgia State University
MRI studies of early brain development in autism Courchesne, Eric University of California, San Diego
Neurophysiological indices of risk and outcome in autism Webb, Sara; Dawson, Geraldine University of Washington
Oxytocin biology and the social deficits of autism spectrum disorders Parker, Karen Stanford University
Signatures of gene expression in ASD Kunkel, Louis Boston Children's Hospital
The genetic link between autism and structural cerebellar malformations Millen, Kathleen University of Chicago

Objective Multiyear Funding Table

IACC Strategic Plan Objectives 2008 2009 2010 2011 2012 Total
Identify behavioral and biological markers that separately, or in combination, accurately identify, before age 2, one or more subtypes of children at risk for developing ASD, and evaluate whether these risk markers or profiles can improve early identification through heightened developmental monitoring and screening by 2014.

IACC Recommended Budget: $33,300,000 over 5 years
14 projects

43 projects

45 projects

43 projects

40 projects

1.L.A. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.

Progress: More than 40 projects have been supported in this area, but most projects are still in the discovery phase. Identifying reliable early biomarkers has been challenging, but some progress has been made. More work is needed to achieve the full intent of the objective.

Remaining Gaps, Needs, and Opportunities:  Remaining research needs include continued discovery of biomarkers, linking biomarkers to treatment response, validation of biomarkers discovered in high risk populations for applicability in the general population, and evaluation of whether these biomarkers translate to improvement in screening and diagnosis real-world settings. There is also a need for biomarkers that are cost-effective.