|Project Title||Principal Investigator||Institution|
|A longitudinal MRI study of infants at risk for autism||Piven, Joseph||University of North Carolina at Chapel Hill|
|A longitudinal MRI study of infants at risk for autism- Supplemental||Piven, Joseph||University of North Carolina at Chapel Hill|
|Analysis of brain microstructure in autism using novel diffusion MRI approaches||Conturo, Thomas||Washington University School of Medicine|
|Assessing information processing and capacity for understanding language in non-verbal children with autism||Benasich, April; Valerie Schafer||Rutgers University; City University of New York|
|Autism spectrum disorder and the visual analysis of human motion||Shiffrar, Maggie||Rutgers, The State University of New Jersey|
|Behavioral and functional neuroimaging investigations of visual perception and cognition in autistics||Mottron, Laurent||Université de Montréal|
|Collaborative neuropathology workgroup: A comprehensive multilevel analysis of frontal lobe microstructure in autism||Courchesne, Eric||University of California, San Diego|
|Communication and prosody in autism: A pilot fMRI study using a sib-pair design||Gusnard, Debra||Washington University in St. Louis|
|Cortical mechanisms underlying visual motion processing impairments in autism||Chen, Yue||Harvard Medical School|
|Dendritic organization within the cerebral cortex in autism||Gabbott, Paul||The Open University|
|Development of brain connectivity in autism||Castellanos, F. Xavier; Lord, Catherine||New York University Medical College; University of Michigan|
|Electrical measures of functional cortical connectivity in autism||Murias, Michael||University of Washington|
|Exploring functional brain connectivity for visual cognition in autism spectrum disorder||Joseph, Jane||University of Kentucky|
|Family characterization network - 1||Santangelo, Susan||Massachusetts General Hospital|
|Family characterization network - 2||Tager-Flusberg, Helen||Boston University School of Medicine|
|FMRI evidence of genetic influence on rigidity in ASD||Lee, Jillian||University of Michigan|
|FMRI studies of cerebellar functioning in autism||Mosconi, Matthew||University of Illinois at Chicago|
|Functional MRI of attention regulation in people with and without autism||Vaidya, Chandan||Georgetown University|
|Gamma band dysfunction as a local neuronal connectivity endophenotype in autism||Rojas, Donald||University of Colorado Denver|
|Impacts of parenting adolescents & adults with autism||Seltzer, Marsha||University of Wisconsin - Madison|
|Informational and neural bases of empathic accuracy in autism spectrum disorder||Zaki, Jamil||Columbia University|
|Investigation of cortical folding complexity in children with autism, their autism-discordant siblings, and controls||Barnea-Goraly, Naama||Stanford University|
|Investigation of the link between early brain enlargement and abnormal functional connectivity in autism spectrum disorders||Kleinhans, Natalia||University of Washington|
|Linguistic perspective-taking in adults with high-functioning autism: Investigation of the mirror neuron system||Mizuno, Akiko||Carnegie Mellon University|
|Longitudinal neurogenetics of atypical social brain development in autism||Pelphrey, Kevin||Yale University|
|IACC Strategic Plan Objectives||2008||2009||2010||2011||2012||Total|
|Complete a large-scale, multidisciplinary, collaborative project that longitudinally and comprehensively examines how the biological, clinical, and developmental profiles of individuals, with a special emphasis on females, youths, and adults with ASD, change over time as compared to typically developing people by 2020.
IACC Recommended Budget: $126,200,000 over 12 years
|2.L.A. Funding: The recommended budget was partially met.
Progress: Several projects have been funded in this area, and the ACE Network continues to collect data relevant to this objective.
Remaining Gaps, Needs and Opportunities: Though this research is underway, more clinical studies are needed over a longer trajectory to identify issues faced as people with ASD age, especially with regard to risk factors for other medical conditions. Another remaining need is that of standardization of data collection and analysis methods.