Strategic Plan Objective Detail
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Question 3: Objective 8  

Fiscal Year: 2008

Green dot: Objective has greater than or equal to the recommended funding.3.8 Identify genetic risk factors in at least 50% of people with ASD by 2014. IACC Recommended Budget: $33,900,000 over 6 years.

Download 2008 Question 3: Objective 8 projects (EXCEL)
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Institution
A California population-based twin study of autism Hallmayer, Joachim Stanford University
A genome-wide search for autism genes in the Simons Simplex Collection State, Matthew Yale University
A molecular genetic study of autism and related phenotypes in extended pedigrees Piven, Joseph University of North Carolina at Chapel Hill
A recurrent genetic cause of autism Gusella, James Massachusetts General Hospital
A system biology approach to autism genetics Geschwind, Daniel University of California, Los Angeles
Autism and SNPs in the IGF pathway Levine, Arnold Princeton University
Autism Genetic Resource Exchange (AGRE) Lajonchere, Clara Autism Speaks
Autism Genome Project (AGP) Shih, Andy Autism Speaks
Center for genomic and phenomic studies in autism Lajonchere, Clara University of Southern California
Central vasopressin receptors and affiliation Young, Larry Emory University
Chromatin remodeling and neuronal differentiation Pazin, Michael National Institutes of Health
Clinical and bioinformatics core Pericak-Vance, Margaret Duke University
Clinical trial: Genomic copy number variation in autism Pomeroy, John Stony Brook University, The State University of New York
Comprehensive follow-up of novel autism genetic discoveries Daly, Mark Massachusetts General Hospital
Core--genomics/bioinformatics--Alzheimer's disease and autism Gilliam, Thomas Columbia University
Demonstration of the novel RASL/DASL method for analysis of gene expression in frontal cortex in autism and control cases Courchesne, Eric University of California, San Diego
Dense mapping of candidate regions linked to autistic disorder Gregersen, Peter Feinstein Institute For Medical Research
Determining the genetic basis of autism by hi-resolution analysis of copy number Sebat, Jonathan Cold Spring Harbor Laboratory
Epigenetic etiologies of autism spectrum disorders LaSalle, Janine University of California, Davis
Etiology of autism risk involving MET gene and the environment Van de Water, Judy University of California, Davis
Exploring the role of CC2D1A in neuronal development and synaptic function Walsh, Christopher Harvard University
Gene expression profiling of autism spectrum disorders Collins, Christin Boston Children's Hospital
Gene finding - 1 Gusella, James Massachusetts General Hospital
Gene finding - 2 Walsh, Christopher Boston Children's Hospital
Gene silencing in fragile X syndrome Usdin, Karen National Institutes of Health

Objective Multiyear Funding Table

IACC Strategic Plan Objectives 2008 2009 2010 2011 2012 Total
Identify genetic risk factors in at least 50% of people with ASD by 2014.

IACC Recommended Budget: $33,900,000 over 6 years
83 projects

79 projects

60 projects

59 projects

74 projects

3.L.B. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.

Progress: Further work is needed to identify genetic risk factors in at least 50% of people. Currently, whole exome analysis predicts that a genetic risk factor can be identified for 20% of people; inclusion of CNV data might push this toward 30%.

Remaining Gaps, Needs, and Opportunities: The initial budget recommendation for this objective was made based on the assumption that GWAS studies would provide risk factor identification, but sequencing has proven more fruitful. Since this technique is more expensive, a higher budget will be required to meet the goal of 50%.