|Project Title||Principal Investigator||Institution|
|A California population-based twin study of autism||Hallmayer, Joachim||Stanford University|
|A genome-wide search for autism genes in the Simons Simplex Collection||State, Matthew||Yale University|
|A molecular genetic study of autism and related phenotypes in extended pedigrees||Piven, Joseph||University of North Carolina at Chapel Hill|
|A recurrent genetic cause of autism||Gusella, James||Massachusetts General Hospital|
|A system biology approach to autism genetics||Geschwind, Daniel||University of California, Los Angeles|
|Autism and SNPs in the IGF pathway||Levine, Arnold||Princeton University|
|Autism Genetic Resource Exchange (AGRE)||Lajonchere, Clara||Autism Speaks|
|Autism Genome Project (AGP)||Shih, Andy||Autism Speaks|
|Center for genomic and phenomic studies in autism||Lajonchere, Clara||University of Southern California|
|Central vasopressin receptors and affiliation||Young, Larry||Emory University|
|Chromatin remodeling and neuronal differentiation||Pazin, Michael||National Institutes of Health|
|Clinical and bioinformatics core||Pericak-Vance, Margaret||Duke University|
|Clinical trial: Genomic copy number variation in autism||Pomeroy, John||Stony Brook University, The State University of New York|
|Comprehensive follow-up of novel autism genetic discoveries||Daly, Mark||Massachusetts General Hospital|
|Core--genomics/bioinformatics--Alzheimer's disease and autism||Gilliam, Thomas||Columbia University|
|Demonstration of the novel RASL/DASL method for analysis of gene expression in frontal cortex in autism and control cases||Courchesne, Eric||University of California, San Diego|
|Dense mapping of candidate regions linked to autistic disorder||Gregersen, Peter||Feinstein Institute For Medical Research|
|Determining the genetic basis of autism by hi-resolution analysis of copy number||Sebat, Jonathan||Cold Spring Harbor Laboratory|
|Epigenetic etiologies of autism spectrum disorders||LaSalle, Janine||University of California, Davis|
|Etiology of autism risk involving MET gene and the environment||Van de Water, Judy||University of California, Davis|
|Exploring the role of CC2D1A in neuronal development and synaptic function||Walsh, Christopher||Harvard University|
|Gene expression profiling of autism spectrum disorders||Collins, Christin||Boston Children's Hospital|
|Gene finding - 1||Gusella, James||Massachusetts General Hospital|
|Gene finding - 2||Walsh, Christopher||Boston Children's Hospital|
|Gene silencing in fragile X syndrome||Usdin, Karen||National Institutes of Health|
|IACC Strategic Plan Objectives||2008||2009||2010||2011||2012||Total|
|Identify genetic risk factors in at least 50% of people with ASD by 2014.
IACC Recommended Budget: $33,900,000 over 6 years
|3.L.B. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.
Progress: Further work is needed to identify genetic risk factors in at least 50% of people. Currently, whole exome analysis predicts that a genetic risk factor can be identified for 20% of people; inclusion of CNV data might push this toward 30%.
Remaining Gaps, Needs, and Opportunities: The initial budget recommendation for this objective was made based on the assumption that GWAS studies would provide risk factor identification, but sequencing has proven more fruitful. Since this technique is more expensive, a higher budget will be required to meet the goal of 50%.