Strategic Plan Objective Detail
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Question 4: Objective 5  

Fiscal Year: 2008

Green dot: Objective has greater than or equal to the recommended funding.4.5 Standardize and validate at least 20 model systems (e.g. cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.

Download 2008 Question 4: Objective 5 projects (EXCEL)
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Project Title Principal Investigator Institution
Aberrant synaptic function due to TSC mutation in autism Sulzer, David Columbia University Medical Center
A better understanding of the therapeutic actions of specific neuroleptics in autism Greengard, Paul The Rockefeller University
A mouse knock-in model for Engrailed 2 autism susceptibility Millonig, James University of Medicine & Dentistry of New Jersey - Robert Wood Johnson Medical School
Analysis of 15q11-13 GABA-A receptor defects in autism Hogart, Amber University of California, Davis
Analysis of FGF17 roles and regulation in mammalian forebrain development Hoch, Renee University of California, San Francisco
Animal models of neuropsychiatric disorders Crawley, Jacqueline National Institutes of Health
A non-human primate autism model based on maternal infection Patterson, Paul California Institute of Technology
Cellular and molecular alterations in gabaergic inhibitory circuits by mutations in MECP2, a gene implicated in the Rett syndrome of the autism spectrum disorders Huang, Z. Josh Cold Spring Harbor Laboratory
Cognitive mechanisms of serially organized behavior Terrace, Herbert Columbia University
Connectopathic analysis of autism Sanes, Joshua Harvard University
Distinct function of the neuroligin 3 postsynaptic adhesion complex Budreck, Elaine Columbia University
Dysregulation of p13/AKT in mouse models for social interaction deficits and for ASD with macrocephaly Parada, Luis University of Texas Southwestern Medical Center
Exploring the role of synaptic proteins in mouse models of autism Heintz, Nathaniel The Rockefeller University
Function and dysfunction of neuroligins Sudhof, Thomas Stanford University
Generation of genetic models of autism in mice Fishell, Gordon New York University School of Medicine
Genetic analyses of ARX homeobox gene function in neurodevelopmental disorders Sengupta, Piali Brandeis University
Genomic imbalances at the 22q11 locus and predisposition to autism Gogos, Joseph Columbia University
Investigation of the role of MET kinase in autism Dawson, Ted Johns Hopkins University School of Medicine
Mice lacking Shank postsynaptic scaffolds as an animal model of autism Sheng, Morgan Massachusetts Institute of Technology
Models and mechanisms - 1 Sur, Mriganka Massachusetts Institute of Technology
Models and mechanisms - 2 Sahin, Mustafa Boston Children's Hospital
Molecular determinants of L-type calcium channel gating Colecraft, Henry Columbia University
Neocortical regionalization: Analysis of genetic and epigenetic influences Huffman, Kelly University of California, Riverside
Neural and cognitive mechanisms of autism Sur, Mriganka Massachusetts Institute of Technology
Neurexin-neuroligin trans-syanptic interaction in learning and memory Kandel, Eric Columbia University