Strategic Plan Objective Detail
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Question 3: Long-term Objective B  

$49,905,587.13
Fiscal Year: 2009

Green dot: Objective has greater than or equal to the recommended funding.3LB. Identify genetic risk factors in at least 50% of people with ASD by 2014. IACC Recommended Budget: $33,900,000 over 6 years.

Download 2009 Question 3: Long-term Objective B projects (EXCEL)
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Institution
Unraveling the genetic etiology of autism Sutcliffe, James Vanderbilt University
Understanding glutamate signaling defects in autism spectrum disorders Wang, Tao Johns Hopkins University
Uncovering genetic mechanisms of ASD Kunkel, Louis Children's Hospital Boston
The role of the Rett gene, chromosone 15Q11-Q13, other genes, and epigenetics Beaudet, Arthur Baylor College of Medicine
The role of the neurexin 1 gene in susceptibility to autism Gusella, James Massachusetts General Hospital/Harvard Medical School
The role of contactin-associated protein-like 2 (CNTNAP2) and other novel genes in autism Chakravarti, Aravinda Johns Hopkins University School of Medicine
The impact of autism specific genomic variations on microRNA gene expression profile Scherer, Stephen The Hospital for Sick Children
Studies of postmortem brain searching for epigenetic defects causing autism Beaudet, Arthur Baylor College of Medicine
Simons Simplex Collection Site Bernier, Raphael University of Washington
Simons Simplex Collection Site Cicero, Theodore Washington University in St. Louis
Simons Simplex Collection Site Cook, Edwin University of Illinois at Chicago
Simons Simplex Collection Site Deutsch, Curtis University of Massachusetts Medical School
Simons Simplex Collection Site Sutcliffe, James Vanderbilt University
Simons Simplex Collection Site Walsh, Christopher Children's Hospital Boston
Simons Simplex Collection Site Fombonne, Eric The Research Institute of the McGill University Health Centre
Simons Simplex Collection Site Geschwind, Daniel University of California, Los Angeles
Simons Simplex Collection Site Klin, Ami Yale University
Simons Simplex Collection Site Kochel, Robin Baylor College of Medicine
Simons Simplex Collection Site Ledbetter, David Emory University
Simons Simplex Collection Site Lord, Catherine University of Michigan
Simons Simplex Collection Site Miles, Judith University of Missouri
Simons Simplex Collection Site Peterson, Bradley Columbia University
Rutgers, The State University of New Jersey Contract Rutgers, The State University of New Jersey
Role of TSC/mTOR signaling pathway in autism and autism spectrum disorders Ramesh, Vijaya Massachusetts General Hospital
Role of micro-RNAs in ASD affected circuit formation and function Ullian, Erik University of California, San Francisco

Objective Cumulative Funding Table

IACC Strategic Plan Objective 2008 2009 2010 2011 2012 Total
Identify genetic risk factors in at least 50% of people with ASD by 2014.

IACC Recommended Budget: $33,900,000 over 6 years
3.8
$37,043,410
83 projects

3.L.B
$49,905,587
79 projects

3.L.B
$34,432,884
60 projects

3.L.B
$25,383,346
59 projects

3.L.B
$23,041,231
74 projects

$169,806,458
3.L.B. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.

Progress: Further work is needed to identify genetic risk factors in at least 50% of people. Currently, whole exome analysis predicts that a genetic risk factor can be identified for 20% of people; inclusion of CNV data might push this toward 30%.

Remaining Gaps, Needs, and Opportunities: The initial budget recommendation for this objective was made based on the assumption that GWAS studies would provide risk factor identification, but sequencing has proven more fruitful. Since this technique is more expensive, a higher budget will be required to meet the goal of 50%.