Strategic Plan Objective Detail
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Question 4: Short-term Objective B  

Fiscal Year: 2010

Green dot: Objective has greater than or equal to the recommended funding.4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.

Download 2010 Question 4: Short-term Objective B projects (EXCEL)
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Project Title Principal Investigator Institution
16p11.2: defining the gene(s) responsible Mills, Alea Cold Spring Harbor Laboratory
A mouse knock-in model for ENGRAILED 2 autism susceptibility Millonig, James University of Medicine & Dentistry of New Jersey
Analysis of cortical circuits related to ASD gene candidates Zador, Anthony Cold Spring Harbor Laboratory
Animal model of speech sound processing in autism Kilgard, Michael University of Texas at Dallas
Animal models of autism: Pathogenesis and treatment Powell, Craig University of Texas Southwestern Medical Center
Animal models of neuropsychiatric disorders Crawley, Jacqueline National Institutes of Health
A novel cell-based assay for autism research and drug discovery Restifo, Linda University of Arizona
A preclinical model for determining the role of AVPR1A in autism spectrum disorders Charles, Rhonda Mount Sinai School of Medicine
Autism iPSCs for studying function and dysfunction in human neural development Loring, Jeanne The Scripps Research Institute
Basal ganglia circuitry and molecules in pathogenesis of motor stereotypy Yang, Xiangdong University of California, Los Angeles
Behavioral and physiological consequences of disrupted Met signaling Levitt, Pat University of Southern California
Caspr2 dysfunction in autism spectrum disorders Robbins, Elissa Yale University
Cellular and genetic correlates of increased head size in autism spectrum disorder Vaccarino, Flora Yale University
Central vasopressin receptors and affiliation Young, Larry Emory University
Central vasopressin receptors and affiliation Young, Larry Emory University
Characterization of a novel mouse model of restricted repetitive behaviors Moy, Sheryl University of North Carolina at Chapel Hill
Characterization of autism susceptibility genes on chromosome 15q11-13 Smith, Stephen Beth Israel Deaconess Medical Center
Characterization of the transcriptome in an emerging model for social behavior Thomas, James Emory University
Cntnap2 in a behavioral model of autism White, Stephanie University of California, Los Angeles
Control of synaptic protein synthesis in the pathogenesis and therapy of autism Kelleher, Raymond Massachusetts General Hospital
Deriving neuroprogenitor cells from peripheral blood of individuals with autism Fujinami, Robert University of Utah
Development of a high-content neuronal assay to screen therapeutics for the treatment of cognitive dysfunction in autism spectrum disorders Bear, Mark Massachusetts Institute of Technology
Dissecting the circuitry basis of autistic-like behaviors in mice Feng, Guoping Massachusetts Institute of Technology
Dissecting the neural control of social attachment Shah, Nirao University of California, San Francisco
Dynamic regulation of Shank3 and ASD Worley, Paul Johns Hopkins University