Strategic Plan Objective Detail
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Question 1: Long-term Objective A  

$13,270,044.50
Fiscal Year: 2010

Green dot: Objective has greater than or equal to the recommended funding.1LA. Identify behavioral and biological markers that separately, or in combination, accurately identify, before age 2, one or more subtypes of children at risk for developing ASD, and evaluate whether these risk markers or profiles can improve early identification through heightened developmental monitoring and screening by 2014. IACC Recommended Budget: $33,300,000 over 5 years.

Download 2010 Question 1: Long-term Objective A projects (EXCEL)
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Institution
Validation study of atypical dynamic pupillary light reflex as a biomarker for autism Yao, Gang; Miles, Judith; Christ, Shawn University of Missouri
Temperament, emotional expression, and emotional self-regulation in relation to later ASD diagnosis Wozniak, Robert Bryn Mawr College
Identifying gastrointestinal (GI) conditions in children with autism spectrum disorders (ASD) Winter, Harland Harvard Medical School
Abnormal vestibulo-ocular reflexes in autism: A potential endophenotype White, Keith University of Florida
Neurophysiological indices of risk and outcome in autism Webb, Sara University of Washington
Multiplexed suspension arrays to investigate newborn and childhood blood samples for potential immune biomarkers of autism Vogt, Robert Centers for Disease Control and Prevention (CDC)
Neurobehavioral research on infants at risk for SLI and autism Tager-Flusberg, Helen; Nelson, Charles Boston University Medical Campus
Family/Genetic study of autism Smith, Christopher Southwestern Autism Research & Resource Center (SARRC)
Neurophysiological investigation of language acquisition in infants at risk for ASD Seery, Anne Boston University
ACE Center: Integrated Biostatistical and Bioinformatic Analysis Core (IBBAC) Schork, Nicholas University of California, San Diego
Placental vascular tree as biomarker of autism/ASD risk Salafia, Carolyn Research Foundation for Mental Hygiene, Inc.
ACE Network: A longitudinal MRI study of infants at risk for autism Piven, Joseph University of North Carolina at Chapel Hill
Supplement to NIH ACE Network grant: "A longitudinal MRI study of infants at risk for autism" Piven, Joseph University of North Carolina at Chapel Hill
Studying the biology and behavior of autism at 1-year: The Well-Baby Check-Up approach Pierce, Karen University of California, San Diego
ACE Center: Clinical Phenotype: Recruitment and Assessment Core Pierce, Karen University of California, San Diego
Temporal coordination of social communicative behaviors in infant siblings of children with autism Parlade, Meaghan University of Pittsburgh
Oxytocin biology and the social deficits of autism spectrum disorders Parker, Karen Stanford University
Infants at risk of autism: A longitudinal study Ozonoff, Sally University of California, Davis
Electrophysiological, metabolic and behavioral markers of infants at risk Nelson, Charles Children's Hospital Boston
Signatures of gene expression in autism spectrum disorders Kunkel, Louis Children's Hospital Boston
RNA expression studies in autism spectrum disorders Kunkel, Louis Children's Hospital Boston
ACE Center: Linguistic and social responses to speech in infants at risk for autism Kuhl, Patricia University of Washington
The ontogeny of social visual engagement in infants at risk for autism Klin, Ami Yale University
ACE Center: Assessment Core Klin, Ami Yale University
Physical and clinical infrastructure for research on infants-at-risk for autism at Yale Klin, Ami Yale University

Objective Cumulative Funding Table

IACC Strategic Plan Objective 2008 2009 2010 2011 2012 Total
Identify behavioral and biological markers that separately, or in combination, accurately identify, before age 2, one or more subtypes of children at risk for developing ASD, and evaluate whether these risk markers or profiles can improve early identification through heightened developmental monitoring and screening by 2014.

IACC Recommended Budget: $33,300,000 over 5 years
1.3
$2,885,940
14 projects

1.L.A
$16,465,034
43 projects

1.L.A
$13,270,045
45 projects

1.L.A
$12,416,466
43 projects

1.L.A
$12,894,621
40 projects

$57,932,106
1.L.A. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.

Progress: More than 40 projects have been supported in this area, but most projects are still in the discovery phase. Identifying reliable early biomarkers has been challenging, but some progress has been made. More work is needed to achieve the full intent of the objective.

Remaining Gaps, Needs, and Opportunities: Remaining research needs include continued discovery of biomarkers, linking biomarkers to treatment response, validation of biomarkers discovered in high risk populations for applicability in the general population, and evaluation of whether these biomarkers translate to improvement in screening and diagnosis real-world settings. There is also a need for biomarkers that are cost-effective.