|Project Title||Principal Investigator||Institution|
|Identifying autism susceptibility genes by high-throughput chip resequencing||Zwick, Michael||Emory University|
|Mutation analysis of candidate genes derived from an autism protein interaction network in SSC autism samples||Zoghbi, Huda||Baylor College of Medicine|
|Vasopressin receptors and social attachment||Young, Larry||Emory University|
|Central vasopressin receptors and affiliation||Young, Larry||Emory University|
|Genomic resources for identifying genes regulating social behavior||Young, Larry||Emory University|
|Genetic contributions to endophenotypes of autism||Wijsman, Ellen||University of Washington|
|Genetic basis of autism||Wigler, Michael||Cold Spring Harbor Laboratory|
|Understanding glutamate signaling defects in autism spectrum disorders||Wang, Tao||Johns Hopkins University|
|Gene finding - 2||Walsh, Christopher||Boston Children's Hospital|
|Simons Simplex Collection Site - 13||Walsh, Christopher||Boston Children's Hospital|
|Recessive genes for autism and mental retardation||Walsh, Christopher||Beth Israel Deaconess Medical Center|
|Exploring the role of CC2D1A in neuronal development and synaptic function||Walsh, Christopher||Harvard University|
|Identification of autism candidate genes on the X-chromosome from copy number variants identified by 500K SNP-CHIP analysis||Vincent, John||Centre For Addiction And Mental Health|
|Identification and functional assessment of autism susceptibility genes - 3||Vieland, Veronica||The Research Institute at Nationwide Children's Hospital|
|Etiology of autism risk involving MET gene and the environment||Van de Water, Judy||University of California, Davis|
|Gene silencing in fragile X syndrome||Usdin, Karen||National Institutes of Health|
|Role of micro-RNAs in ASD affected circuit formation and function||Ullian, Erik||University of California, San Francisco|
|Neuroligin and autism||Taylor, Palmer||University of California, San Diego|
|Potential role of noncoding RNAs in autism||Talebizadeh, Zohreh||Children's Mercy Hospitals and Clinics|
|Hindbrain dysgenesis in Rett syndrome and other autism spectrum disorders||Swanberg, Susan||University of California, Davis|
|Simons Simplex Collection Site - 12||Sutcliffe, James||Vanderbilt University|
|Genetic analysis of 15q11-q13 in autism||Sutcliffe, James||Vanderbilt University|
|Unraveling the genetic etiology of autism||Sutcliffe, James||Vanderbilt University|
|Isolation of autism susceptibility genes||Stefansson, Kari||Decode Genetics, Inc.|
|A genome-wide search for autism genes in the Simons Simplex Collection||State, Matthew||Yale University|
|IACC Strategic Plan Objectives||2008||2009||2010||2011||2012||Total|
|Identify genetic risk factors in at least 50% of people with ASD by 2014.
IACC Recommended Budget: $33,900,000 over 6 years
|3.L.B. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.
Progress: Further work is needed to identify genetic risk factors in at least 50% of people. Currently, whole exome analysis predicts that a genetic risk factor can be identified for 20% of people; inclusion of CNV data might push this toward 30%.
Remaining Gaps, Needs, and Opportunities: The initial budget recommendation for this objective was made based on the assumption that GWAS studies would provide risk factor identification, but sequencing has proven more fruitful. Since this technique is more expensive, a higher budget will be required to meet the goal of 50%.