Strategic Plan Objective Detail
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Question 4: Objective 5  

Fiscal Year: 2008

Green dot: Objective has greater than or equal to the recommended funding.4.5 Standardize and validate at least 20 model systems (e.g. cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.

Download 2008 Question 4: Objective 5 projects (EXCEL)
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Project Title Principal Investigator Institution
Regulation of gene expression in the brain Young, Walter National Institutes of Health
Probing a monogenic form of autism from molecules to behavior Tsien, Richard Stanford University
Regulation of synaptogenesis by cyclin dependent kinase 5 Tsai, Li-Huei Massachusetts Institute of Technology
Cognitive mechanisms of serially organized behavior Terrace, Herbert Columbia University
Models and mechanisms - 1 Sur, Mriganka Massachusetts Institute of Technology
Neural and cognitive mechanisms of autism Sur, Mriganka Massachusetts Institute of Technology
Aberrant synaptic function due to TSC mutation in autism Sulzer, David Columbia University Medical Center
Function and dysfunction of neuroligins Sudhof, Thomas Stanford University
Using zebrafish and chemical screening to define function of autism genes Sive, Hazel Whitehead Institute for Biomedical Research
Mice lacking Shank postsynaptic scaffolds as an animal model of autism Sheng, Morgan Massachusetts Institute of Technology
Genetic analyses of ARX homeobox gene function in neurodevelopmental disorders Sengupta, Piali Brandeis University
Connectopathic analysis of autism Sanes, Joshua Harvard University
Oxidative stress: Rat study Sajdel-Sulkowska, Ellen Brigham and Women's Hospital
Models and mechanisms - 2 Sahin, Mustafa Boston Children's Hospital
Perturbed activity dependent plasticity mechanisms in autism Sabatini, Bernardo Harvard Medical School
Role of Wnt signaling through Dishevelled, Dact and p120catenin in forebrain development, synaptic physiology, and mouse behavior: Exploration of a pathway with many components linked to autism spectrum disorders Reichardt, Louis University of California, San Francisco
A non-human primate autism model based on maternal infection Patterson, Paul California Institute of Technology
Dysregulation of p13/AKT in mouse models for social interaction deficits and for ASD with macrocephaly Parada, Luis University of Texas Southwestern Medical Center
Role of L-type calcium channels in hippocampal neuronal network activity Owen, Scott Stanford University
Novel models to define the genetic basis of autism Mills, Alea Cold Spring Harbor Laboratory
A mouse knock-in model for Engrailed 2 autism susceptibility Millonig, James University of Medicine & Dentistry of New Jersey - Robert Wood Johnson Medical School
The functional neuroanatomy of memory systems in the human brain Martin, Alex National Institutes of Health
Neurodevelopmental mechanisms of social behavior Levitt, Pat Vanderbilt University
Testing the effects of cortical disconnection in non-human primates Krauzlis, Richard Salk Institute for Biological Studies
Neurexin-neuroligin trans-syanptic interaction in learning and memory Kandel, Eric Columbia University