Strategic Plan Objective Detail
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Question 2: Short-term Objective A  

Fiscal Year: 2009

Green dot: Objective has greater than or equal to the recommended funding.2SA. Support at least four research projects to identify mechanisms of metabolic and/or immune system interactions with the central nervous system that may underlie the development of ASD during prenatal-postnatal life by 2010. IACC Funding Budget: $9,800,000 over 4 years.

Download 2009 Question 2: Short-term Objective A projects (EXCEL)
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Project Title Principal Investigator Institution
Redox abnormalities as a vulnerability phenotype for autism and related alterations in CNS development James, Sandra Arkansas Children's Hospital Research Institute
How does IL-6 mediate the development of autism-related behaviors? Hsiao, Elaine California Institute of Technology
A non-human primate autism model based on maternal infection Patterson, Paul California Institute of Technology
Mechanisms of mitochondrial dysfunction in autism Shoffner, John Georgia State University
Relationship between celiac disease and autism Russo, A.J. Health Research Institute
Gene-environment interactions in the pathogenesis of autism-like neurodevelopmental damage: A mouse model Pletnikov, Mikhail Johns Hopkins University School of Medicine
Repository for tissues from children with and without autism Kushak, Rafail Massachusetts General Hospital
Neuroimmunologic investigations of autism spectrum disorders (ASD) Swedo, Susan National Institutes of Health (NIH)
Regulation of inflammatory Th17 cells in autism spectrum disorder Littman, Dan New York University School of Medicine
Influence of oxidative stress on transcription and alternative splicing of methionine synthase in autism Muratore, Christina Northeastern University
Modulation of neuronal cysteine uptake and redox status by morphine, gluten/casein-derived opiates and naltrexone Deth, Richard Northeastern University School of Pharmacy
Evaluation and treatment of copper/zinc imbalance in children with autism Ramer, Jeanette Penn State Milton S. Hershey Medical Center
Maternal inflammation alters fetal brain development via tumor necrosis factor-alpha Carpentier, Pamela Stanford University
Maternal infection and autism: Impact of placental sufficiency and maternal inflammatory responses on fetal brain development Palmer, Theo Stanford University
Redox abnormalities as a vulnerability phenotype for autism and related alterations in CNS development Hepel, Maria State University of New York at Potsdam
The pathogenesis of autism: Maternal antibody exposure in the fetal brain Diamond, Betty The Feinstein Institute for Medical Research
Consequences of maternal antigen exposure on offspring immunity: An animal model of vertical tolerance Rall, Glenn The Fox Chase Cancer Center
CD8 + T lymphocyte function in autism Ashwood, Paul University of California, Davis
CD8 + T lymphocyte function in autism Ashwood, Paul University of California, Davis
Primate models of autism Bauman, Melissa University of California, Davis
Project 2: Immunological susceptibility of autism Van de Water, Judy University of California, Davis
A role for immune molecules in cortical connectivity: Potential implications for autism Elmer, Bradford University of California, Davis
Is autism a mitochondrial disease? Giulivi, Cecilia University of California, Davis
Immune molecules and cortical synaptogenesis: Possible implications for the pathogenesis of autism McAllister, A. Kimberley University of California, Davis
A mitochondrial etiology of autism Wallace, Douglas University of California, Irvine