Strategic Plan Objective Detail
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Question 2: Short-term Objective D  

Fiscal Year: 2009

New! Yellow dot: Objective has some degree of funding, but less than the recommended amount.2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.

Download 2009 Question 2: Short-term Objective D projects (EXCEL)
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Project Title Principal Investigator Institution
Role of neuroligins in long-term plasticity at excitatory and inhibitory synapses Engelman, Holly Albert Einstein College of Medicine of Yeshiva University
Role of excitation and inhibition in Rett syndrome Chao, Hsiao-Tuan Baylor College of Medicine
Elucidating the roles of SHANK3 and FXR in the autism interactome Zoghbi, Huda Baylor College of Medicine
Clinical correlations of contiguous gene syndromes Potocki, Lorraine Baylor College of Medicine
Visual system connectivity in a high-risk model of autism Sahin, Mustafa Children's Hospital Boston
The functional link between DISC1 and neuroligins: Two genetic factors in the etiology of autism Morris, Jill Children's Memorial Hospital, Chicago
Neural circuit deficits in animal models of Rett syndrome Xiong, Qiaojie Cold Spring Harbor Laboratory
Cell type-based genomics of developmental plasticity in cortical GABA interneurons Huang, Z. Josh Cold Spring Harbor Laboratory
Cell-based genomic analysis in mouse models of Rett syndrome Huang, Z. Josh Cold Spring Harbor Laboratory
Cellular and molecular alterations in GABAergic inhibitor circuits by mutations in MeCP2 Huang, Z. Josh Cold Spring Harbor Laboratory
Aberrant synaptic function caused by TSC mutation in autism Sulzer, David Columbia University
Neuroligin regulation of central GABAergic synapses Fu, Zhanyan Duke University
Fundamental mechanisms of GPR56 activation and regulation Hall, Randy Emory University
Connectopathic analysis of autism Sanes, Joshua Harvard University
The microRNA pathway in translational regulation of neuronal development Gao, Fen-Biao J. David Gladstone Institutes
Olfactory abnormalities in the modeling of Rett syndrome Ronnett, Gabriele Johns Hopkins University
An adult brain-specific mouse model of neuronal TSC inactivation Kelleher, Raymond Massachusetts General Hospital
Investigation of postnatal drug intervention's potential in rescuing the symptoms of fragile X syndrome in adult mice Sidorov, Michael Massachusetts Institute of Technology
Gene silencing in fragile X syndrome Usdin, Karen National Institutes of Health (NIH)
Translation regulation in hippocampal LTP and LTD Klann, Eric New York University
Autism iPSCs for studying function and dysfunction in human neural development Loring, Jeanne Scripps Research Institute
White matter connections of the face processing network in children and adults Yoon, Jennifer Stanford University
Synaptic analysis of neuroligin 1 function Fuccillo, Marc Stanford University
Augmentation of the cholinergic system in fragile X syndrome: A double-blind placebo-controlled randomized study of donepezil Reiss, Allan Stanford University
Probing a monogenic form of autism from molecules to behavior Tsien, Richard Stanford University