Strategic Plan Objective Detail
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Question 3: Objective 8  

$37,043,409.82
Fiscal Year: 2008

Green dot: Objective has greater than or equal to the recommended funding.3.8 Identify genetic risk factors in at least 50% of people with ASD by 2014. IACC Recommended Budget: $33,900,000 over 6 years.

Download 2008 Question 3: Objective 8 projects (EXCEL)
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Institution
Autism Genetic Resource Exchange (AGRE) Lajonchere, Clara Autism Speaks
Autism Genome Project (AGP) Shih, Andy Autism Speaks
The role of the Rett gene, chromosome 15q11-q13, other genes, and epigenetics Beaudet, Arthur Baylor College of Medicine
Studies of postmortem brain searching for epigenetic defects causing autism Beaudet, Arthur Baylor College of Medicine
Simons Simplex Collection Site - 1 Beaudet, Arthur Baylor College of Medicine
Mutation analysis of candidate genes derived from an autism protein interaction network in SSC autism samples Zoghbi, Huda Baylor College of Medicine
Recessive genes for autism and mental retardation Walsh, Christopher Beth Israel Deaconess Medical Center
Uncovering genetic mechanisms of ASD Kunkel, Louis Boston Children's Hospital
Gene expression profiling of autism spectrum disorders Collins, Christin Boston Children's Hospital
Simons Simplex Collection Site - 13 Walsh, Christopher Boston Children's Hospital
Gene finding - 2 Walsh, Christopher Boston Children's Hospital
Neuronal populations related to deficits in social emotions and cognition in autism: A neurobiological and genomics approach Allman, John California Institute of Technology
Identification of autism candidate genes on the X-chromosome from copy number variants identified by 500K SNP-CHIP analysis Vincent, John Centre For Addiction And Mental Health
Potential role of noncoding RNAs in autism Talebizadeh, Zohreh Children's Mercy Hospitals and Clinics
Determining the genetic basis of autism by hi-resolution analysis of copy number Sebat, Jonathan Cold Spring Harbor Laboratory
Genetic basis of autism Wigler, Michael Cold Spring Harbor Laboratory
Core--genomics/bioinformatics--Alzheimer's disease and autism Gilliam, Thomas Columbia University
Simons Simplex Collection Site - 11 Peterson, Bradley Columbia University
Isolation of autism susceptibility genes Stefansson, Kari Decode Genetics, Inc.
Molecular analysis core Pericak-Vance, Margaret Duke University
Neurogenetics of candidate systems in autism Haines, Jonathan Duke University
Clinical and bioinformatics core Pericak-Vance, Margaret Duke University
Genetic studies in autism on chromosome 7 Pericak-Vance, Margaret Duke University
Genomic resources for identifying genes regulating social behavior Young, Larry Emory University
Identifying autism susceptibility genes by high-throughput chip resequencing Zwick, Michael Emory University

Objective Cumulative Funding Table

IACC Strategic Plan Objectives 2008 2009 2010 2011 2012 Total
Identify genetic risk factors in at least 50% of people with ASD by 2014.

IACC Recommended Budget: $33,900,000 over 6 years
3.8
$37,043,410
83 projects

3.L.B
$49,905,587
79 projects

3.L.B
$34,432,884
60 projects

3.L.B
$25,383,346
59 projects

3.L.B
$23,041,231
74 projects

$169,806,458
3.L.B. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.

Progress: Further work is needed to identify genetic risk factors in at least 50% of people. Currently, whole exome analysis predicts that a genetic risk factor can be identified for 20% of people; inclusion of CNV data might push this toward 30%.

Remaining Gaps, Needs, and Opportunities: The initial budget recommendation for this objective was made based on the assumption that GWAS studies would provide risk factor identification, but sequencing has proven more fruitful. Since this technique is more expensive, a higher budget will be required to meet the goal of 50%.